OBJECTIVES: To study whether NRAMP1 gene polymorphisms in a Japanese population affect susceptibility to tuberculosis and clinical features of tuberculosis. METHODS: Polymerase chain reaction and restriction fragment-length polymorphism analyses were used to type NRAMP1 polymorphisms in 95 patients with pulmonary tuberculosis and 90 controls. Clinical features of patients also were investigated. RESULTS: No association was seen between susceptibility to tuberculosis and NRAMP1 polymorphisms. Patients with the D543N A allele were significantly more likely than others to develop a cavitary lesion; by logistic regression analysis with adjustment for gender, age, and presence of diabetes, the odds ratio in patients with an A allele was 5.16 (95% confidence interval, 1.30-20.45). CONCLUSIONS: Genetic variation in the human NRAMP1 gene may be associated with cavitation in patients with tuberculosis.
OBJECTIVES: To study whether NRAMP1 gene polymorphisms in a Japanese population affect susceptibility to tuberculosis and clinical features of tuberculosis. METHODS: Polymerase chain reaction and restriction fragment-length polymorphism analyses were used to type NRAMP1 polymorphisms in 95 patients with pulmonary tuberculosis and 90 controls. Clinical features of patients also were investigated. RESULTS: No association was seen between susceptibility to tuberculosis and NRAMP1 polymorphisms. Patients with the D543N A allele were significantly more likely than others to develop a cavitary lesion; by logistic regression analysis with adjustment for gender, age, and presence of diabetes, the odds ratio in patients with an A allele was 5.16 (95% confidence interval, 1.30-20.45). CONCLUSIONS: Genetic variation in the humanNRAMP1 gene may be associated with cavitation in patients with tuberculosis.
Authors: Robert J Greenstein; Liya Su; Irene R Grant; Antonio C G Foddai; Amy Turner; Jason S Nagati; Sheldon T Brown; Judith R Stabel Journal: Gut Pathog Date: 2021-05-06 Impact factor: 4.181
Authors: Kim Hung Leung; Shea Ping Yip; Wa Sang Wong; Lap San Yiu; Kam Keung Chan; Wai Man Lai; Eudora Y D Chow; Che Kit Lin; Wing Cheong Yam; Kin Sang Chan Journal: BMC Infect Dis Date: 2007-03-19 Impact factor: 3.090