Literature DB >> 12798322

Fundamental structure-activity relationships associated with a new structural class of respiratory syncytial virus inhibitor.

Kuo Long Yu1, Yi Zhang, Rita L Civiello, Kathleen F Kadow, Christopher Cianci, Mark Krystal, Nicholas A Meanwell.   

Abstract

Structure-activity relationships surrounding the dialkylamino side chain of a series of benzotriazole-derived inhibitors of respiratory syncytial virus fusion based on the screening lead 1a were examined. The results indicate that the topology of the side chain is important but the terminus element offers considerable latitude to modulate physical properties.

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Year:  2003        PMID： 12798322     DOI： 10.1016/s0960-894x(03)00383-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  21 in total

1.  Mild and General Access to Diverse 1H-Benzotriazoles via Diboron-Mediated N-OH Deoxygenation and Palladium-Catalyzed C-C and C-N Bond Formation.

Authors:  Venkateshwarlu Gurram; Hari K Akula; Ramesh Garlapati; Narender Pottabathini; Mahesh K Lakshman
Journal:  Adv Synth Catal       Date:  2015-02-09       Impact factor: 5.837

2.  Engineering and expression of a RhoA peptide against respiratory syncytial virus infection in plants.

Authors:  Benita Ortega-Berlanga; Konstantin Musiychuk; Yoko Shoji; Jessica A Chichester; Vidadi Yusibov; Omar Patiño-Rodríguez; Daniel E Noyola; Ángel G Alpuche-Solís
Journal:  Planta       Date:  2015-10-16       Impact factor: 4.116

3.  The Disappearing Director: The Case of Directed N-Arylation via a Removable Hydroxyl Group.

Authors:  Magdalena R Andrzejewska; Prasanna K Vuram; Narender Pottabathini; Venkateshwarlu Gurram; Siva Subrahmanyam Relangi; Kirill A Korvinson; Raju Doddipalla; Lothar Stahl; Michelle C Neary; Padmanava Pradhan; Somesh Sharma; Mahesh K Lakshman
Journal:  Adv Synth Catal       Date:  2018-04-16       Impact factor: 5.837

4.  Blocking Respiratory Syncytial Virus Entry: A Story with Twists.

Authors:  Marco Weisshaar; Robert Cox; Richard K Plemper
Journal:  DNA Cell Biol       Date:  2015-05-11       Impact factor: 3.311

5.  Discovery of (aza)indole derivatives as novel respiratory syncytial virus fusion inhibitors.

Authors:  Xiufang Zheng; Chungen Liang; Lisha Wang; Kun Miao; Baoxia Wang; Weixing Zhang; Dongdong Chen; Guolong Wu; Wei Zhu; Lei Guo; Song Feng; Lu Gao; Hong C Shen; Hongying Yun
Journal:  Medchemcomm       Date:  2019-05-06       Impact factor: 3.597

6.  Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms.

Authors:  Janet L Douglas; Marites L Panis; Edmund Ho; Kuei-Ying Lin; Steve H Krawczyk; Deborah M Grant; Ruby Cai; Swami Swaminathan; Xiaowu Chen; Tomas Cihlar
Journal:  Antimicrob Agents Chemother       Date:  2005-06       Impact factor: 5.191

7.  2-(1H-Benzotriazol-1-yl)-1-phenyl-ethanol.

Authors:  Ozden Ozel Güven; Meral Bayraktar; Simon J Coles; Tuncer Hökelek
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-03-27

8.  1-[2-(4-Chloro-benz-yloxy)-2-phenyl-ethyl]-1H-benzotriazole.

Authors:  Ozden Ozel Güven; Meral Bayraktar; Simon J Coles; Tuncer Hökelek
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-05-08

9.  Orally active fusion inhibitor of respiratory syncytial virus.

Authors:  Christopher Cianci; Kuo-Long Yu; Keith Combrink; Ny Sin; Bradley Pearce; Alan Wang; Rita Civiello; Stacey Voss; Guangxiang Luo; Kathy Kadow; Eugene V Genovesi; Brian Venables; Hatice Gulgeze; Ashok Trehan; Jennifer James; Lucinda Lamb; Ivette Medina; Julia Roach; Zheng Yang; Lisa Zadjura; Richard Colonno; Junius Clark; Nicholas Meanwell; Mark Krystal
Journal:  Antimicrob Agents Chemother       Date:  2004-02       Impact factor: 5.191

10.  A new polymorph of 2-(2H-benzotriazol-2-yl)acetic acid.

Authors:  Guloy Alieva; Jamshid Ashurov; Nasir Mukhamedov; Nusrat Parpiev
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-09-01
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