OBJECTIVE: To assess the hypnotic effect of melatonin in patients with primary insomnia. METHOD:Ten patients (mean age 50 yr, range 30-72 yr) who met the DSM-IV criteria for primary insomnia received, in random order, 0.3 mg ofmelatonin, 1.0 mg of melatonin or placebo 60 minutes before bedtime. A crossover design was used so that each patient received each of the 3 treatments for a 7-day period (with a 5-day washout period between). After each 7-day treatment, night time electroencephalographic (EEG) records were collected, and each morning, subjects completed sleep logs and analogue-visual scales to document the amount and subjective quality of sleep. RESULTS: There were no significant differences in sleep EEG, the amount or subjective quality of sleep or side effects between the placebo, 0.3-mg melatonin or 1.0-mg melatonin treatments. CONCLUSION:Melatonin did not produce any sleep benefit in this sample of patients with primary insomnia.
RCT Entities:
OBJECTIVE: To assess the hypnotic effect of melatonin in patients with primary insomnia. METHOD: Ten patients (mean age 50 yr, range 30-72 yr) who met the DSM-IV criteria for primary insomnia received, in random order, 0.3 mg of melatonin, 1.0 mg of melatonin or placebo 60 minutes before bedtime. A crossover design was used so that each patient received each of the 3 treatments for a 7-day period (with a 5-day washout period between). After each 7-day treatment, night time electroencephalographic (EEG) records were collected, and each morning, subjects completed sleep logs and analogue-visual scales to document the amount and subjective quality of sleep. RESULTS: There were no significant differences in sleep EEG, the amount or subjective quality of sleep or side effects between the placebo, 0.3-mg melatonin or 1.0-mg melatonin treatments. CONCLUSION:Melatonin did not produce any sleep benefit in this sample of patients with primary insomnia.
Authors: E McNamara; C F Reynolds; P H Soloff; R Mathias; A Rossi; D Spiker; P A Coble; D J Kupfer Journal: Am J Psychiatry Date: 1984-02 Impact factor: 18.112
Authors: Nina Buscemi; Ben Vandermeer; Nicola Hooton; Rena Pandya; Lisa Tjosvold; Lisa Hartling; Glen Baker; Terry P Klassen; Sunita Vohra Journal: J Gen Intern Med Date: 2005-12 Impact factor: 5.128
Authors: Rebecca B Costello; Cynthia V Lentino; Courtney C Boyd; Meghan L O'Connell; Cindy C Crawford; Meredith L Sprengel; Patricia A Deuster Journal: Nutr J Date: 2014-11-07 Impact factor: 3.271