Literature DB >> 12787000

The distribution of 13 killer-cell immunoglobulin-like receptor loci in UK blood donors from three ethnic groups.

M A Cook1, P A H Moss, D C Briggs.   

Abstract

Killer-cell immunoglobulin-like receptors (KIRs) can inhibit the killing activity of natural killer (NK) cells if they interact with their ligand, class I HLA. Using a modified polymerase chain reaction-sequence-specific primers (PCR-SSP) method for typing KIRs using genomic DNA, we compared KIR frequencies in three ethnic populations drawn from UK blood donors. We found a significantly lower frequency of the inhibitory KIRs KIR2DS1 and 3DS1 in Afro-Caribbean blood donors. Despite this, there was a (non-significant) increase in the B haplotype in Afro-Caribbean and Indian Asian donors. Some donors from each group tested negative for all non-inhibitory KIRs. In addition, we describe several new KIR profiles. Analysis of linkage disequilibrium was consistent with previously published findings.

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Year:  2003        PMID： 12787000     DOI： 10.1046/j.1365-2370.2003.00394.x

Source DB:  PubMed          Journal:  Eur J Immunogenet        ISSN： 0960-7420


  13 in total

1.  Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela.

Authors:  A Conesa; M Fernández-Mestre; D Padrón; F Toro; N Silva; P Tassinari; I Blanca; M P Martin; M Carrington; Z Layrisse
Journal:  Tissue Antigens       Date:  2010-02-24

2.  Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes.

Authors:  Katharine C Hsu; Carolyn A Keever-Taylor; Andrew Wilton; Clara Pinto; Glenn Heller; Knarik Arkun; Richard J O'Reilly; Mary M Horowitz; Bo Dupont
Journal:  Blood       Date:  2005-02-24       Impact factor: 22.113

3.  An improved RT-PCR method for the detection of killer-cell immunoglobulin-like receptor (KIR) transcripts.

Authors:  A Thompson; A R van der Slik; F Koning; J van Bergen
Journal:  Immunogenetics       Date:  2006-10-11       Impact factor: 2.846

4.  Receptor-ligand analyses define minimal killer cell Ig-like receptor (KIR) in humans.

Authors:  Zeying Du; David W Gjertson; Elaine F Reed; Raja Rajalingam
Journal:  Immunogenetics       Date:  2006-11-14       Impact factor: 2.846

5.  Asian population frequencies and haplotype distribution of killer cell immunoglobulin-like receptor (KIR) genes among Chinese, Malay, and Indian in Singapore.

Authors:  Yi Chuan Lee; Soh Ha Chan; Ee Chee Ren
Journal:  Immunogenetics       Date:  2008-07-31       Impact factor: 2.846

6.  The diversity of KIR gene in Chinese Northern Han population and the impact of donor KIR and patient HLA genotypes on outcome following HLA-identical sibling allogeneic hematopoietic stem cell transplantation for hematological malignancy in Chinese people.

Authors:  Li Ping Dou; De Hua Zheng; Chang Wang; Jun Hua Liu; Jing Fen Sun; Hai Jie Jin; Chun Ji Gao; Li Yu; Wan Ming Da
Journal:  Int J Hematol       Date:  2008-05       Impact factor: 2.490

7.  Comparison of the rapidly evolving KIR locus in Parsis and natives of India.

Authors:  S Kulkarni; R M Single; M P Martin; R Rajalingam; R Badwe; N Joshi; M Carrington
Journal:  Immunogenetics       Date:  2008-03-20       Impact factor: 2.846

8.  SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complex.

Authors:  Paul J Norman; Mark A Cook; B Sean Carey; Christine V F Carrington; David H Verity; Kamran Hameed; D Dan Ramdath; Dasnayanee Chandanayingyong; Mark Leppert; Henry A F Stephens; R W Vaughan
Journal:  Immunogenetics       Date:  2004-06-05       Impact factor: 2.846

9.  Distribution of killer cell immunoglobulin-like receptors genes in the Italian Caucasian population.

Authors:  A Bontadini; M Testi; M C Cuccia; M Martinetti; C Carcassi; A Chiesa; E Cosentini; E Dametto; S Frison; A M Iannone; C Lombardo; A Malagoli; M Mariani; L Mariotti; L Mascaretti; L Mele; V Miotti; S Nesci; G Ozzella; D Piancatelli; G Romeo; C Tagliaferri; S Vatta; M Andreani; R Conte
Journal:  J Transl Med       Date:  2006-10-27       Impact factor: 5.531

10.  KIR haplotypes defined by segregation analysis in 59 Centre d'Etude Polymorphisme Humain (CEPH) families.

Authors:  M P Martin; R M Single; M J Wilson; J Trowsdale; M Carrington
Journal:  Immunogenetics       Date:  2008-10-30       Impact factor: 2.846
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