Literature DB >> 12783535

Novel binding and efficient cellular uptake of guanidine-based peptide nucleic acids (GPNA).

Peng Zhou1, Miaomiao Wang, Lei Du, Gregory W Fisher, Alan Waggoner, Danith H Ly.   

Abstract

Incorporation of a guanidine functional group into the PNA backbone facilitates cellular uptake of PNA into mammalian cells with efficiency comparable to that of the TAT transduction domain. The modified PNA recognizes and binds to the complementary DNA strand in accordance with Watson-Crick recognition rules. However, unlike polypyrimidine PNA which binds to DNA in 2:1 stoichiometry, the modified PNA binds to complementary DNA in a 1:1 ratio to form a highly stable duplex.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12783535     DOI： 10.1021/ja029665m

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  45 in total

1.  Recognition of double-stranded RNA by guanidine-modified peptide nucleic acids.

Authors:  Pankaj Gupta; Oluwatoyosi Muse; Eriks Rozners
Journal:  Biochemistry       Date:  2011-12-20       Impact factor: 3.162

Review 2.  Targeting DNA G-quadruplex structures with peptide nucleic acids.

Authors:  Igor G Panyutin; Mykola I Onyshchenko; Ethan A Englund; Daniel H Appella; Ronald D Neumann
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

Review 3.  The design of guanidinium-rich transporters and their internalization mechanisms.

Authors:  Paul A Wender; Wesley C Galliher; Elena A Goun; Lisa R Jones; Thomas H Pillow
Journal:  Adv Drug Deliv Rev       Date:  2007-11-09       Impact factor: 15.470

4.  Toward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis.

Authors:  Paul A Wender
Journal:  Tetrahedron       Date:  2013-06-07       Impact factor: 2.457

5.  Improvement of sequence selectivity in triple helical recognition of RNA by phenylalanine-derived PNA.

Authors:  Thomas Zengeya; Artem Gindin; Eriks Rozners
Journal:  Artif DNA PNA XNA       Date:  2013-10-08

6.  Dimeric cationic amphiphilic polyproline helices for mitochondrial targeting.

Authors:  Iris M Geisler; Jean Chmielewski
Journal:  Pharm Res       Date:  2011-06-07       Impact factor: 4.200

Review 7.  Therapeutic applications of an expanded genetic code.

Authors:  Sophie B Sun; Peter G Schultz; Chan Hyuk Kim
Journal:  Chembiochem       Date:  2014-07-18       Impact factor: 3.164

8.  Cell-Penetrating, Guanidinium-Rich Oligophosphoesters: Effective and Versatile Molecular Transporters for Drug and Probe Delivery.

Authors:  Colin J McKinlay; Robert M Waymouth; Paul A Wender
Journal:  J Am Chem Soc       Date:  2016-03-07       Impact factor: 15.419

9.  Orientation preferences of backbone secondary amide functional groups in peptide nucleic acid complexes: quantum chemical calculations reveal an intrinsic preference of cationic D-amino acid-based chiral PNA analogues for the P-form.

Authors:  Christopher M Topham; Jeremy C Smith
Journal:  Biophys J       Date:  2006-10-27       Impact factor: 4.033

10.  Loop and backbone modifications of peptide nucleic acid improve g-quadruplex binding selectivity.

Authors:  Sabrina Lusvarghi; Connor T Murphy; Subhadeep Roy; Farial A Tanious; Iulia Sacui; W David Wilson; Danith H Ly; Bruce A Armitage
Journal:  J Am Chem Soc       Date:  2009-12-30       Impact factor: 15.419
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.