Literature DB >> 12781179

Unexpected inhibition of S-adenosyl-L-homocysteine hydrolase by a guanosine nucleoside.

Katherine L Seley1, Stephen Quirk, Samer Salim, Liang Zhang, Asmerom Hagos.   

Abstract

A series of shape-modified flexible nucleosides ('fleximers', 1, 2, and 3) was modeled, synthesized and subsequently assayed against S-adenosyl-L-homocysteine hydrolase (SAHase). No inhibitory activity was observed for the adenosine fleximer, which served as a substrate, but moderate inhibitory activity was exhibited by the guanosine fleximers. This is the first known report of a guanosine nucleoside analogue possessing activity against SAHase.

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Year:  2003        PMID： 12781179     DOI： 10.1016/s0960-894x(03)00331-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  16 in total

1.  Carbocyclic 5'-nor "reverse" fleximers. Design, synthesis, and preliminary biological activity.

Authors:  Sarah C Zimmermann; Joshua M Sadler; Graciela Andrei; Robert Snoeck; Jan Balzarini; Katherine L Seley-Radtke
Journal:  Medchemcomm       Date:  2011-07-01       Impact factor: 3.597

2.  Carbocyclic pyrimidine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase.

Authors:  Sylvester L Mosley; Brian A Bakke; Joshua M Sadler; Naresh K Sunkara; Kathleen M Dorgan; Zhaohui Sunny Zhou; Katherine L Seley-Radtke
Journal:  Bioorg Med Chem       Date:  2006-08-10       Impact factor: 3.641

3.  Synthetic Routes to a Series of Proximal and Distal 2'-Deoxy Fleximers.

Authors:  Orrette R Wauchope; Melvin Velasquez; Katherine Seley-Radtke
Journal:  Synthesis (Stuttg)       Date:  2012       Impact factor: 3.157

4.  "Reverse" carbocyclic fleximers: synthesis of a new class of adenosine deaminase inhibitors.

Authors:  Sarah C Zimmermann; Joshua M Sadler; Peter I O'Daniel; Nathaniel T Kim; Katherine L Seley-Radtke
Journal:  Nucleosides Nucleotides Nucleic Acids       Date:  2013       Impact factor: 1.381

5.  "Reverse fleximers": introduction of a series of 5-substituted carbocyclic uridine analogues.

Authors:  Joshua M Sadler; Olubukola Ojewoye; Katherine L Seley-Radtke
Journal:  Nucleic Acids Symp Ser (Oxf)       Date:  2008

6.  Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity.

Authors:  Hannah L Peters; Dirk Jochmans; Adriaan H de Wilde; Clara C Posthuma; Eric J Snijder; Johan Neyts; Katherine L Seley-Radtke
Journal:  Bioorg Med Chem Lett       Date:  2015-05-23       Impact factor: 2.823

Review 7.  Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses.

Authors:  Luděk Eyer; Radim Nencka; Erik de Clercq; Katherine Seley-Radtke; Daniel Růžek
Journal:  Antivir Chem Chemother       Date:  2018 Jan-Dec

Review 8.  Flexibility-Not just for yoga anymore!

Authors:  Katherine Seley-Radtke
Journal:  Antivir Chem Chemother       Date:  2018 Jan-Dec

9.  Flex-nucleoside analogues - Novel therapeutics against filoviruses.

Authors:  Mary K Yates; Mithun R Raje; Payel Chatterjee; Christina F Spiropoulou; Sina Bavari; Mike Flint; Veronica Soloveva; Katherine L Seley-Radtke
Journal:  Bioorg Med Chem Lett       Date:  2017-04-22       Impact factor: 2.823

10.  An Expedient Synthesis of Flexible Nucleosides through Enzymatic Glycosylation of Proximal and Distal Fleximer Bases.

Authors:  Sophie Vichier-Guerre; Therese C Ku; Sylvie Pochet; Katherine L Seley-Radtke
Journal:  Chembiochem       Date:  2020-02-27       Impact factor: 3.461
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