BACKGROUND AND PURPOSE: We investigated the usefulness of central retinal artery (CRA) Doppler flowmetry in patients with cerebral small-vessel disease (SVD). METHODS: CRA Doppler flowmetry was performed in 103 SVD patients who underwent MRI. Sixty-four adjusted control subjects were also registered. We assessed average CRA flow parameter values for both eyes with the clinical and MRI findings. RESULTS: Each Doppler flowmetry was performed within 5 minutes. Patients with SVD had significantly lower end-diastolic and mean velocities of the CRA than control subjects; they also had higher pulsatility and resistive indexes. Multivariate analysis showed that the number of small infarcts was an independent predictor of peak systolic and mean velocities. Grade of periventricular hyperintensities was an additional independent predictor of peak systolic and mean velocities, whereas the number of small infarcts was predictive of end-diastolic velocity. CONCLUSIONS: Flow parameters may be useful for the quantitative assessment of SVD severity.
BACKGROUND AND PURPOSE: We investigated the usefulness of central retinal artery (CRA) Doppler flowmetry in patients with cerebral small-vessel disease (SVD). METHODS: CRA Doppler flowmetry was performed in 103 SVDpatients who underwent MRI. Sixty-four adjusted control subjects were also registered. We assessed average CRA flow parameter values for both eyes with the clinical and MRI findings. RESULTS: Each Doppler flowmetry was performed within 5 minutes. Patients with SVD had significantly lower end-diastolic and mean velocities of the CRA than control subjects; they also had higher pulsatility and resistive indexes. Multivariate analysis showed that the number of small infarcts was an independent predictor of peak systolic and mean velocities. Grade of periventricular hyperintensities was an additional independent predictor of peak systolic and mean velocities, whereas the number of small infarcts was predictive of end-diastolic velocity. CONCLUSIONS: Flow parameters may be useful for the quantitative assessment of SVD severity.
Authors: Ali Kord Valeshabad; Justin Wanek; Faisal Mukarram; Ruth Zelkha; Fernando D Testai; Mahnaz Shahidi Journal: Microvasc Res Date: 2015-04-24 Impact factor: 3.514
Authors: Amir H Kashani; Samuel Asanad; Jane W Chan; Maxwell B Singer; Jiong Zhang; Mona Sharifi; Maziyar M Khansari; Farzan Abdolahi; Yonggang Shi; Alessandro Biffi; Helena Chui; John M Ringman Journal: Prog Retin Eye Res Date: 2021-01-15 Impact factor: 19.704
Authors: Oluwagbemiga O Ayoola; Rahman A Bolarinwa; Oluwatoyin H Onakpoya; Stephen O Onigbinde; Christianah M Asaleye; Akinola A Odedeyi Journal: Ultrasonography Date: 2019-07-05