Literature DB >> 15155677

Helicobacter pylori induces AGS cell motility and elongation via independent signaling pathways.

Stefan Moese1, Matthias Selbach, Terry Kwok, Volker Brinkmann, Wolfgang König, Thomas F Meyer, Steffen Backert.   

Abstract

Helicobacter pylori induces motogenic and cytoskeletal responses in gastric epithelial cells. We demonstrate that these responses can be induced via independent signaling pathways that often occur in parallel. The cag pathogenicity island appears to be nonessential for induction of motility, whereas the elongation phenotype depends on translocation and phosphorylation of CagA.

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Year:  2004        PMID： 15155677      PMCID： PMC415712          DOI： 10.1128/IAI.72.6.3646-3649.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  13 in total

1.  SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein.

Authors:  Hideaki Higashi; Ryouhei Tsutsumi; Syuichi Muto; Toshiro Sugiyama; Takeshi Azuma; Masahiro Asaka; Masanori Hatakeyama
Journal:  Science       Date:  2001-12-13       Impact factor: 47.728

2.  Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8.

Authors:  W Fischer; J Püls; R Buhrdorf; B Gebert; S Odenbreit; R Haas
Journal:  Mol Microbiol       Date:  2001-12       Impact factor: 3.501

3.  Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori.

Authors:  E D Segal; J Cha; J Lo; S Falkow; L S Tompkins
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-07       Impact factor: 11.205

4.  Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells.

Authors:  S Backert; S Moese; M Selbach; V Brinkmann; T F Meyer
Journal:  Mol Microbiol       Date:  2001-11       Impact factor: 3.501

5.  Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo.

Authors:  Matthias Selbach; Stefan Moese; Christof R Hauck; Thomas F Meyer; Steffen Backert
Journal:  J Biol Chem       Date:  2002-01-11       Impact factor: 5.157

6.  c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs.

Authors:  Markus Stein; Fabio Bagnoli; Robert Halenbeck; Rino Rappuoli; Wendy J Fantl; Antonello Covacci
Journal:  Mol Microbiol       Date:  2002-02       Impact factor: 3.501

7.  Attenuation of Helicobacter pylori CagA x SHP-2 signaling by interaction between CagA and C-terminal Src kinase.

Authors:  Ryouhei Tsutsumi; Hideaki Higashi; Megumi Higuchi; Masato Okada; Masanori Hatakeyama
Journal:  J Biol Chem       Date:  2002-11-21       Impact factor: 5.157

8.  The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation.

Authors:  Matthias Selbach; Stefan Moese; Robert Hurwitz; Christof R Hauck; Thomas F Meyer; Steffen Backert
Journal:  EMBO J       Date:  2003-02-03       Impact factor: 11.598

9.  Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response.

Authors:  Yuri Churin; Laila Al-Ghoul; Oliver Kepp; Thomas F Meyer; Walter Birchmeier; Michael Naumann
Journal:  J Cell Biol       Date:  2003-04-28       Impact factor: 10.539

Review 10.  Tyrosine-phosphorylated bacterial proteins: Trojan horses for the host cell.

Authors:  A Covacci; R Rappuoli
Journal:  J Exp Med       Date:  2000-02-21       Impact factor: 14.307
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  30 in total

1.  Morphology and infectivity of virus that persistently caused infection in an AGS cell line.

Authors:  Yukimasa Ooi; Eriko Daikoku; Hong Wu; Hiroaki Aoki; Chizuko Morita; Takashi Nakano; Takehiro Kohno; Tomohiko Takasaki; Kouichi Sano
Journal:  Med Mol Morphol       Date:  2011-12-17       Impact factor: 2.309

2.  Paxillin is a novel cellular target for converging Helicobacter pylori-induced cellular signaling.

Authors:  Fazal H Tabassam; David Y Graham; Yoshio Yamaoka
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2011-07-14       Impact factor: 4.052

Review 3.  Role of Helicobacter pylori in gastric cancer: Updates.

Authors:  Jahanarah Khatoon; Ravi Prakash Rai; Kashi Nath Prasad
Journal:  World J Gastrointest Oncol       Date:  2016-02-15

4.  Helicobacter pylori CagA induces AGS cell elongation through a cell retraction defect that is independent of Cdc42, Rac1, and Arp2/3.

Authors:  Kevin M Bourzac; Crystal M Botham; Karen Guillemin
Journal:  Infect Immun       Date:  2006-12-28       Impact factor: 3.441

5.  Characterization of the pilin ortholog of the Helicobacter pylori type IV cag pathogenicity apparatus, a surface-associated protein expressed during infection.

Authors:  Joanna Andrzejewska; Sae Kyung Lee; Patrick Olbermann; Nina Lotzing; Elena Katzowitsch; Bodo Linz; Mark Achtman; Clarence I Kado; Sebastian Suerbaum; Christine Josenhans
Journal:  J Bacteriol       Date:  2006-08       Impact factor: 3.490

6.  The beta1 integrin activates JNK independent of CagA, and JNK activation is required for Helicobacter pylori CagA+-induced motility of gastric cancer cells.

Authors:  Jared L Snider; Cody Allison; Bryan H Bellaire; Richard L Ferrero; James A Cardelli
Journal:  J Biol Chem       Date:  2008-03-20       Impact factor: 5.157

7.  CagL polymorphisms between East Asian and Western Helicobacter pylori are associated with different abilities to induce IL-8 secretion.

Authors:  Yun Hui Choi; Jing Lai; Myeong-A Kim; Aeryun Kim; Jinmoon Kim; Hanfu Su; Linhu Ge; Jeong-Heon Cha
Journal:  J Microbiol       Date:  2021-06-01       Impact factor: 3.422

8.  Expression of CagL from Helicobacter pylori and Preliminary Study of its Biological Function.

Authors:  Hua Wang; Shiteng Huang; Jianzhong Zhao; Jun Han; Xianwei Guan; Shihe Shao
Journal:  Indian J Microbiol       Date:  2012-12-15       Impact factor: 2.461

9.  OipA plays a role in Helicobacter pylori-induced focal adhesion kinase activation and cytoskeletal re-organization.

Authors:  Fazal H Tabassam; David Y Graham; Yoshio Yamaoka
Journal:  Cell Microbiol       Date:  2007-12-06       Impact factor: 3.715

10.  Helicobacter pylori counteracts the apoptotic action of its VacA toxin by injecting the CagA protein into gastric epithelial cells.

Authors:  Amanda Oldani; Mireille Cormont; Veronique Hofman; Valentina Chiozzi; Olivier Oregioni; Alexandra Canonici; Anna Sciullo; Patrizia Sommi; Alessia Fabbri; Vittorio Ricci; Patrice Boquet
Journal:  PLoS Pathog       Date:  2009-10-02       Impact factor: 6.823
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