| Literature DB >> 12773154 |
J R Coggins1, C Abell, L B Evans, M Frederickson, D A Robinson, A W Roszak, A P Lapthorn.
Abstract
The background and current context of work on the shikimate-pathway enzymes as potential targets for anti-bacterial, anti-fungal and anti-parasitic drugs is reviewed. Recent work on the third enzyme of the pathway, dehydroquinase, which occurs in two structurally and mechanistically distinct forms, is used to illustrate the present state of studies into rational drug design.Mesh：
Substances：
Year: 2003 PMID： 12773154 DOI： 10.1042/bst0310548
Source DB: PubMed Journal: Biochem Soc Trans ISSN： 0300-5127 Impact factor: 5.407