OBJECTIVE: To evaluate the effects of COX-1 and/or COX-2 inhibition in a model of chronic esophagitis in rabbits. METHODS: Both high- and low-grade esophagitis were induced in rabbits by the perfusion of acidified pepsin. Rabbits were treated with either a selective COX-2 inhibitor (DFU[3-(3-Fluorophenyl)-4-(4-Methanesulfonyl)-5,5-Dimethyl-5H-Furan-2-One];30 mg/Kg/day), a nonspecific COX inhibitor (indomethacin; 2 mg/Kg/day), or a COX-1 preferential inhibitor (piroxicam; 2 mg/Kg/12 h). RESULTS: Prostaglandins are derived from COX-1 activity in the normal esophagus. Both low- and high-grade esophagitis are associated with a progressive increase of COX activity, which is partially dependent on the COX-2 isoform. DFU reduced muscosal damage in both models of esophagitis. However, indomethacin did not affect significantly mucosal damage, and piroxicam increased damage in low-grade esophagitis. CONCLUSIONS: COX-1 activity is constitutive in the rabbit esophageal mucosa, but both COX-2 and COX-1 activity are increased under the impact of acidified pepsin. Treatment with the COX-2 inhibitor DFU is associated with improvement of mucosal damage, which may have therapeutic implications.
OBJECTIVE: To evaluate the effects of COX-1 and/or COX-2 inhibition in a model of chronic esophagitis in rabbits. METHODS: Both high- and low-grade esophagitis were induced in rabbits by the perfusion of acidified pepsin. Rabbits were treated with either a selective COX-2 inhibitor (DFU[3-(3-Fluorophenyl)-4-(4-Methanesulfonyl)-5,5-Dimethyl-5H-Furan-2-One];30 mg/Kg/day), a nonspecific COX inhibitor (indomethacin; 2 mg/Kg/day), or a COX-1 preferential inhibitor (piroxicam; 2 mg/Kg/12 h). RESULTS:Prostaglandins are derived from COX-1 activity in the normal esophagus. Both low- and high-grade esophagitis are associated with a progressive increase of COX activity, which is partially dependent on the COX-2 isoform. DFU reduced muscosal damage in both models of esophagitis. However, indomethacin did not affect significantly mucosal damage, and piroxicam increased damage in low-grade esophagitis. CONCLUSIONS:COX-1 activity is constitutive in the rabbit esophageal mucosa, but both COX-2 and COX-1 activity are increased under the impact of acidified pepsin. Treatment with the COX-2 inhibitor DFU is associated with improvement of mucosal damage, which may have therapeutic implications.
Authors: D Riendeau; M D Percival; S Boyce; C Brideau; S Charleson; W Cromlish; D Ethier; J Evans; J P Falgueyret; A W Ford-Hutchinson; R Gordon; G Greig; M Gresser; J Guay; S Kargman; S Léger; J A Mancini; G O'Neill; M Ouellet; I W Rodger; M Thérien; Z Wang; J K Webb; E Wong; C C Chan Journal: Br J Pharmacol Date: 1997-05 Impact factor: 8.739
Authors: T Hayakawa; Y Fujiwara; M Hamaguchi; T Sugawa; M Okuyama; E Sasaki; T Watanabe; K Tominaga; N Oshitani; K Higuchi; T Arakawa Journal: Gut Date: 2005-10-06 Impact factor: 23.059
Authors: C Poplawski; D Sosnowski; A Szaflarska-Popławska; J Sarosiek; R McCallum; Z Bartuzi Journal: World J Gastroenterol Date: 2006-03-21 Impact factor: 5.742
Authors: Paula Esquivias; Antonio Morandeira; Alfredo Escartín; Carmelo Cebrián; Sonia Santander; Francisco Esteva; María Asunción García-González; Javier Ortego; Angel Lanas; Elena Piazuelo Journal: World J Gastroenterol Date: 2012-09-21 Impact factor: 5.742