Literature DB >> 12772502

Cellular uptake and intracellular fate of antisense oligonucleotides.

Alain R Thierry1, Eric Vives, Jean-Philippe Richard, Paul Prevot, Camille Martinand-Mari, Ian Robbins, Bernard Lebleu.   

Abstract

Antisense oligonucleotides and short interfering RNAs are routinely used for gene function analysis and are being developed for clinical applications. The mechanism underlying internalization of free oligonucleotides into cells is poorly understood and inefficient in most cases. Antisense oligonucleotide delivery into ex vivo cells is routinely improved by the addition of cationic lipids. New chemical modifications and vectors allowing improved cellular delivery in vivo are being developed.

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Year:  2003        PMID： 12772502

Source DB:  PubMed          Journal:  Curr Opin Mol Ther        ISSN： 1464-8431


  12 in total

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Journal:  Pharm Res       Date:  2004-03       Impact factor: 4.200

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Authors:  Thibaut Michel; Camille Martinand-Mari; Françoise Debart; Bernard Lebleu; Ian Robbins; Jean-Jacques Vasseur
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Review 10.  Epigenetic manipulation of gene expression: a toolkit for cell biologists.

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