Literature DB >> 12770700

Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice.

Martine Poncelet1, Jeanne Maruani, Roselyne Calassi, Philippe Soubrié.   

Abstract

Administration of the cannabinoid CB1 receptor antagonist SR141716 (3-10 mg/kg i.p.) abolished neuropeptide Y-induced overeating and significantly reduced ethanol and sucrose intake in CB1 wild-type (+/+) mice. In CB1 receptor knockout (-/-) mice, neuropeptide Y totally lost its capacity to increase food consumption. Similarly, sucrose and ethanol intakes were significantly lower in CB1-/- vs. CB1+/+ mice. In CB1 deficient mice, SR141716 had no effect in these models.

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Year:  2003        PMID： 12770700     DOI： 10.1016/s0304-3940(03)00397-5

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  42 in total

1.  Selective breeding for high alcohol preference is associated with increased sensitivity to cannabinoid reward within the nucleus accumbens shell.

Authors:  Sheketha R Hauser; Simon N Katner; Robert A Waeiss; William A Truitt; Richard L Bell; William J McBride; Zachary A Rodd
Journal:  Pharmacol Biochem Behav       Date:  2020-07-23       Impact factor: 3.533

2.  The relationship of in vivo central CB1 receptor occupancy to changes in cortical monoamine release and feeding elicited by CB1 receptor antagonists in rats.

Authors:  Anne B Need; Richard J Davis; Jesline T Alexander-Chacko; Brian Eastwood; Eyassu Chernet; Lee A Phebus; Dana K Sindelar; George G Nomikos
Journal:  Psychopharmacology (Berl)       Date:  2005-11-18       Impact factor: 4.530

Review 3.  The cannabinoid CB1 receptor antagonist, rimonabant, as a promising pharmacotherapy for alcohol dependence: preclinical evidence.

Authors:  Giancarlo Colombo; Alessandro Orrù; Paola Lai; Claudia Cabras; Paola Maccioni; Marina Rubio; Gian Luigi Gessa; Mauro A M Carai
Journal:  Mol Neurobiol       Date:  2007-07-03       Impact factor: 5.590

Review 4.  The endocannabinoid system in brain reward processes.

Authors:  M Solinas; S R Goldberg; D Piomelli
Journal:  Br J Pharmacol       Date:  2008-04-14       Impact factor: 8.739

Review 5.  Genes and Alcohol Consumption: Studies with Mutant Mice.

Authors:  J Mayfield; M A Arends; R A Harris; Y A Blednov
Journal:  Int Rev Neurobiol       Date:  2016       Impact factor: 3.230

6.  Innate difference in the endocannabinoid signaling and its modulation by alcohol consumption in alcohol-preferring sP rats.

Authors:  K Yaragudri Vinod; Paola Maccioni; Maria Salud Garcia-Gutierrez; Teresa Femenia; Shan Xie; Mauro A M Carai; Jorge Manzanares; Thomas B Cooper; Basalingappa L Hungund; Giancarlo Colombo
Journal:  Addict Biol       Date:  2011-02-11       Impact factor: 4.280

Review 7.  The utility of animal models to evaluate novel anti-obesity agents.

Authors:  Steven P Vickers; Helen C Jackson; Sharon C Cheetham
Journal:  Br J Pharmacol       Date:  2011-10       Impact factor: 8.739

8.  Reduced sensitivity to reward in CB1 knockout mice.

Authors:  Carles Sanchis-Segura; Brandon H Cline; Giovanni Marsicano; Beat Lutz; Rainer Spanagel
Journal:  Psychopharmacology (Berl)       Date:  2004-04-09       Impact factor: 4.530

9.  Rimonabant (SR141716) has no effect on alcohol self-administration or endocrine measures in nontreatment-seeking heavy alcohol drinkers.

Authors:  David Ted George; David W Herion; Cheryl L Jones; Monte J Phillips; Jacqueline Hersh; Debra Hill; Markus Heilig; Vijay A Ramchandani; Christopher Geyer; David E Spero; Erick D Singley; Stephanie S O'Malley; Raafat Bishai; Robert R Rawlings; George Kunos
Journal:  Psychopharmacology (Berl)       Date:  2009-11-10       Impact factor: 4.530

Review 10.  Cannabinoids in eating disorders and obesity.

Authors:  Francisco Arias Horcajadas
Journal:  Mol Neurobiol       Date:  2007-07-07       Impact factor: 5.590
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