Literature DB >> 17952655

The cannabinoid CB1 receptor antagonist, rimonabant, as a promising pharmacotherapy for alcohol dependence: preclinical evidence.

Giancarlo Colombo1, Alessandro Orrù, Paola Lai, Claudia Cabras, Paola Maccioni, Marina Rubio, Gian Luigi Gessa, Mauro A M Carai.   

Abstract

Several lines of preclinical evidence indicate the ability of the prototypic cannabinoid CB(1) receptor antagonist, rimonabant, to suppress various alcohol-related behaviors, including alcohol drinking and seeking behavior and alcohol self-administration in rats and mice. Together, these data-synthetically reviewed in the present paper-suggest (a) the involvement of the cannabinoid CB(1) receptor in the neural substrate controlling alcohol intake, alcohol reinforcement, and the motivational properties of alcohol and (b) that rimonabant may constitute a new and potentially effective medication for the treatment of alcohol dependence.

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Year:  2007        PMID： 17952655     DOI： 10.1007/s12035-007-0017-y

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  60 in total

1.  Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21.

Authors:  Francisco Javier Pavon; Ainhoa Bilbao; Laura Hernández-Folgado; Andrea Cippitelli; Nadine Jagerovic; Gumersindo Abellán; M A Isabel Rodríguez-Franco; Antonia Serrano; Manuel Macias; Raquel Gómez; Miguel Navarro; Pilar Goya; Fernando Rodríguez de Fonseca
Journal:  Neuropharmacology       Date:  2006-06-05       Impact factor: 5.250

Review 2.  An endocannabinoid mechanism in relapse to drug seeking: a review of animal studies and clinical perspectives.

Authors:  Liana Fattore; M Sabrina Spano; Serena Deiana; Valeria Melis; Gregorio Cossu; Paola Fadda; Walter Fratta
Journal:  Brain Res Rev       Date:  2006-07-12

Review 3.  Involvement of the endocannabinoid system in drug addiction.

Authors:  Rafael Maldonado; Olga Valverde; Fernando Berrendero
Journal:  Trends Neurosci       Date:  2006-02-17       Impact factor: 13.837

4.  Effects of SR141716A on ethanol and sucrose self-administration.

Authors:  C S Freedland; A L Sharpe; H H Samson; L J Porrino
Journal:  Alcohol Clin Exp Res       Date:  2001-02       Impact factor: 3.455

5.  Ethanol-reinforced behaviour in the rat: effects of naltrexone.

Authors:  P Bienkowski; W Kostowski; E Koros
Journal:  Eur J Pharmacol       Date:  1999-06-25       Impact factor: 4.432

Review 6.  Efficacy of rimonabant and other cannabinoid CB1 receptor antagonists in reducing food intake and body weight: preclinical and clinical data.

Authors:  Mauro A M Carai; Giancarlo Colombo; Paola Maccioni; Gian Luigi Gessa
Journal:  CNS Drug Rev       Date:  2006

Review 7.  Interactions between cannabinoid and opioid receptor systems in the mediation of ethanol effects.

Authors:  Jorge Manzanares; Sergio Ortiz; José M Oliva; Sandra Pérez-Rial; Tomás Palomo
Journal:  Alcohol Alcohol       Date:  2004-11-18       Impact factor: 2.826

8.  Cannabinoid receptor agonist-stimulated [35S]guanosine triphosphate gammaS binding in the brain of C57BL/6 and DBA/2 mice.

Authors:  B S Basavarajappa; B L Hungund
Journal:  J Neurosci Res       Date:  2001-05-15       Impact factor: 4.164

9.  Effects of CB1 cannabinoid receptor blockade on ethanol preference after chronic alcohol administration combined with repeated re-exposures and withdrawals.

Authors:  Frédéric Lallemand; Philippe Soubrié; Philippe De Witte
Journal:  Alcohol Alcohol       Date:  2004-10-05       Impact factor: 2.826

Review 10.  Neurobiology of relapse to alcohol in rats.

Authors:  A Lê; Y Shaham
Journal:  Pharmacol Ther       Date:  2002 Apr-May       Impact factor: 12.310
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  21 in total

1.  Alcohol Versus Cannabinoids: A Review of Their Opposite Neuro-Immunomodulatory Effects and Future Therapeutic Potentials.

Authors:  Madhavan P Nair; Gloria Figueroa; Gianna Casteleiro; Karla Muñoz; Marisela Agudelo
Journal:  J Alcohol Drug Depend       Date:  2015-01-23

2.  Genetic Versus Pharmacological Assessment of the Role of Cannabinoid Type 2 Receptors in Alcohol Reward-Related Behaviors.

Authors:  Matthew S Powers; Kristen R Breit; Julia A Chester
Journal:  Alcohol Clin Exp Res       Date:  2015-12       Impact factor: 3.455

3.  Chronic ethanol exposure increases voluntary home cage intake in adult male, but not female, Long-Evans rats.

Authors:  Melissa Morales; Molly M McGinnis; Brian A McCool
Journal:  Pharmacol Biochem Behav       Date:  2015-10-26       Impact factor: 3.533

4.  Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders.

Authors:  Liana Asatryan; Megan M Yardley; Sheraz Khoja; James R Trudell; Nhat Hyunh; Stan G Louie; Nicos A Petasis; Ronald L Alkana; Daryl L Davies
Journal:  Int J Neuropsychopharmacol       Date:  2014-01-22       Impact factor: 5.176

5.  Agonism of the endocannabinoid system modulates binge-like alcohol intake in male C57BL/6J mice: involvement of the posterior ventral tegmental area.

Authors:  D N Linsenbardt; S L Boehm
Journal:  Neuroscience       Date:  2009-08-07       Impact factor: 3.590

6.  Effects of the novel endocannabinoid uptake inhibitor, LY2183240, on fear-potentiated startle and alcohol-seeking behaviors in mice selectively bred for high alcohol preference.

Authors:  Matthew S Powers; Gustavo D Barrenha; Nate S Mlinac; Eric L Barker; Julia A Chester
Journal:  Psychopharmacology (Berl)       Date:  2010-09-14       Impact factor: 4.530

7.  Ivermectin reduces alcohol intake and preference in mice.

Authors:  Megan M Yardley; Letisha Wyatt; Sheraz Khoja; Liana Asatryan; Marcia J Ramaker; Deborah A Finn; Ronald L Alkana; Nhat Huynh; Stan G Louie; Nicos A Petasis; Marco Bortolato; Daryl L Davies
Journal:  Neuropharmacology       Date:  2012-03-23       Impact factor: 5.250

Review 8.  How adaptation of the brain to alcohol leads to dependence: a pharmacological perspective.

Authors:  Peter Clapp; Sanjiv V Bhave; Paula L Hoffman
Journal:  Alcohol Res Health       Date:  2008

9.  Targets for ethanol action and antagonism in loop 2 of the extracellular domain of glycine receptors.

Authors:  Daya I Perkins; James R Trudell; Daniel K Crawford; Ronald L Alkana; Daryl L Davies
Journal:  J Neurochem       Date:  2008-05-12       Impact factor: 5.372

10.  Genetic and pharmacological manipulations of the CB(1) receptor alter ethanol preference and dependence in ethanol preferring and nonpreferring mice.

Authors:  K Yaragudri Vinod; Ratnakumar Yalamanchili; Panayotis K Thanos; Csaba Vadasz; Thomas B Cooper; Nora D Volkow; Basalingappa L Hungund
Journal:  Synapse       Date:  2008-08       Impact factor: 2.562
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