Literature DB >> 12769553

Dynamic glycosylation of the transcription factor CREB: a potential role in gene regulation.

Nathan Lamarre-Vincent1, Linda C Hsieh-Wilson.   

Abstract

We report that CREB (cyclic AMP-responsive element-binding protein), a transcription factor essential for long-term memory, is O-GlcNAc glycosylated in the mammalian brain. Glycosylation occurs at two sites within the Q2 domain and disrupts the interaction between CREB and TAFII130, thereby repressing the transcriptional activity of CREB in vitro. These findings have important implications for the role of O-GlcNAc glycosylation in gene regulation, and they provide a link between O-GlcNAc and information storage processes in the brain.

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Year:  2003        PMID： 12769553     DOI： 10.1021/ja028200t

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  41 in total

1.  Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response.

Authors:  Jayme Salsman; Madhav Jagannathan; Patrick Paladino; Pak-Kei Chan; Graham Dellaire; Brian Raught; Lori Frappier
Journal:  J Virol       Date:  2011-11-09       Impact factor: 5.103

2.  Exploring the O-GlcNAc proteome: direct identification of O-GlcNAc-modified proteins from the brain.

Authors:  Nelly Khidekel; Scott B Ficarro; Eric C Peters; Linda C Hsieh-Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-30       Impact factor: 11.205

3.  Detection and analysis of proteins modified by O-linked N-acetylglucosamine.

Authors:  Natasha E Zachara; Keith Vosseller; Gerald W Hart
Journal:  Curr Protoc Protein Sci       Date:  2011-11

Review 4.  Exploring the emerging complexity in transcriptional regulation of energy homeostasis.

Authors:  Adelheid Lempradl; J Andrew Pospisilik; Josef M Penninger
Journal:  Nat Rev Genet       Date:  2015-10-13       Impact factor: 53.242

Review 5.  Chemical approaches to understanding O-GlcNAc glycosylation in the brain.

Authors:  Jessica E Rexach; Peter M Clark; Linda C Hsieh-Wilson
Journal:  Nat Chem Biol       Date:  2008-02       Impact factor: 15.040

Review 6.  Nutrient regulation of signaling and transcription.

Authors:  Gerald W Hart
Journal:  J Biol Chem       Date:  2019-01-09       Impact factor: 5.157

7.  CREB binds to multiple loci on human chromosome 22.

Authors:  Ghia Euskirchen; Thomas E Royce; Paul Bertone; Rebecca Martone; John L Rinn; F Kenneth Nelson; Fred Sayward; Nicholas M Luscombe; Perry Miller; Mark Gerstein; Sherman Weissman; Michael Snyder
Journal:  Mol Cell Biol       Date:  2004-05       Impact factor: 4.272

8.  Increasing CRTC1 function in the dentate gyrus during memory formation or reactivation increases memory strength without compromising memory quality.

Authors:  Melanie J Sekeres; Valentina Mercaldo; Blake Richards; Derya Sargin; Vivek Mahadevan; Melanie A Woodin; Paul W Frankland; Sheena A Josselyn
Journal:  J Neurosci       Date:  2012-12-05       Impact factor: 6.167

9.  Iron down-regulates leptin by suppressing protein O-GlcNAc modification in adipocytes, resulting in decreased levels of O-glycosylated CREB.

Authors:  Yan Gao; Jingfang Liu; Zhenzhong Bai; Sandy Sink; Chengyu Zhao; Felipe Ramos Lorenzo; Donald A McClain
Journal:  J Biol Chem       Date:  2019-02-01       Impact factor: 5.157

Review 10.  The role of protein O-linked beta-N-acetylglucosamine in mediating cardiac stress responses.

Authors:  John C Chatham; Richard B Marchase
Journal:  Biochim Biophys Acta       Date:  2009-07-14
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