Literature DB >> 12765831

HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins.

Marcin Grynberg1, Heidi Erlandsen, Adam Godzik.   

Abstract

A novel domain - HEPN (higher eukarytoes and prokaryotes nucleotide-binding domain) - found in several bacterial species is also present in the human protein, sacsin, a chaperonin implicated in an early-onset neurodegenerative disease. The distant structural similarity suggests that this domain might be involved in nucleotide binding.

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Year:  2003        PMID： 12765831     DOI： 10.1016/S0968-0004(03)00060-4

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  25 in total

Review 1.  CRISPR-Cas: evolution of an RNA-based adaptive immunity system in prokaryotes.

Authors:  Eugene V Koonin; Kira S Makarova
Journal:  RNA Biol       Date:  2013-02-25       Impact factor: 4.652

2.  Structures of ubiquitin-like (Ubl) and Hsp90-like domains of sacsin provide insight into pathological mutations.

Authors:  Marie Ménade; Guennadi Kozlov; Jean-François Trempe; Harshit Pande; Solomon Shenker; Sihara Wickremasinghe; Xinlu Li; Hamed Hojjat; Marie-Josée Dicaire; Bernard Brais; Peter S McPherson; Michael J H Wong; Jason C Young; Kalle Gehring
Journal:  J Biol Chem       Date:  2018-06-26       Impact factor: 5.157

Review 3.  Nuclease integrated kinase super assemblies (NiKs) and their role in RNA processing.

Authors:  Monica C Pillon; Robin E Stanley
Journal:  Curr Genet       Date:  2017-09-19       Impact factor: 3.886

4.  Structural basis of defects in the sacsin HEPN domain responsible for autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS).

Authors:  Guennadi Kozlov; Alexey Y Denisov; Martine Girard; Marie-Josée Dicaire; Jason Hamlin; Peter S McPherson; Bernard Brais; Kalle Gehring
Journal:  J Biol Chem       Date:  2011-04-20       Impact factor: 5.157

5.  Structure-function analyses reveal the molecular architecture and neutralization mechanism of a bacterial HEPN-MNT toxin-antitoxin system.

Authors:  Xuanyan Jia; Jianyun Yao; Zengqiang Gao; Guangfeng Liu; Yu-Hui Dong; Xiaoxue Wang; Heng Zhang
Journal:  J Biol Chem       Date:  2018-03-19       Impact factor: 5.157

6.  Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes.

Authors:  Kira S Makarova; Yuri I Wolf; Eugene V Koonin
Journal:  Biol Direct       Date:  2009-06-03       Impact factor: 4.540

7.  Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems.

Authors:  Sergey Shmakov; Omar O Abudayyeh; Kira S Makarova; Yuri I Wolf; Jonathan S Gootenberg; Ekaterina Semenova; Leonid Minakhin; Julia Joung; Silvana Konermann; Konstantin Severinov; Feng Zhang; Eugene V Koonin
Journal:  Mol Cell       Date:  2015-10-22       Impact factor: 17.970

8.  Private SACS mutations in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) families from Turkey.

Authors:  Andrea M Richter; Riza Koksal Ozgul; Virginie C Poisson; Haluk Topaloglu
Journal:  Neurogenetics       Date:  2004-05-20       Impact factor: 2.660

9.  It takes two (Las1 HEPN endoribonuclease domains) to cut RNA correctly.

Authors:  Monica C Pillon; Kevin H Goslen; Jacob Gordon; Melissa L Wells; Jason G Williams; Robin E Stanley
Journal:  J Biol Chem       Date:  2020-03-27       Impact factor: 5.157

10.  Structural characterization of aminoglycoside 4'-O-adenylyltransferase ANT(4')-IIb from Pseudomonas aeruginosa.

Authors:  Cameron Semper; Peter Stogios; Djalal Meziane-Cherif; Elena Evdokimova; Patrice Courvalin; Alexei Savchenko
Journal:  Protein Sci       Date:  2020-01-29       Impact factor: 6.725
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