BACKGROUND: The anatomical origin of the enlargement of the cerebral ventricles in schizophrenia is obscure. METHODS: In this study, the volumes of the hemispheres and lateral ventricles were assessed in MRI scans of 43 formalin-fixed brains (23 from patients and 19 comparison subjects) using a spline 'snake' segmentation method. RESULTS: A bilateral ventricular volume increase was found in schizophrenia. Whereas enlargement of the lateral ventricle (mean: 54%) as a whole was related to age of onset and was greater in females than in males, enlargement of the temporal horn (mean: 54%) was not strongly related to age of onset or sex. Lateral ventricle volume was negatively correlated with STG, fusiform and parahippocampal volume in schizophrenia. Hemispheric volumes were unchanged. CONCLUSIONS: The differing correlates of the components of ventricular enlargement suggest a degree of selectivity of the disease process with a focus in the temporal lobe.
BACKGROUND: The anatomical origin of the enlargement of the cerebral ventricles in schizophrenia is obscure. METHODS: In this study, the volumes of the hemispheres and lateral ventricles were assessed in MRI scans of 43 formalin-fixed brains (23 from patients and 19 comparison subjects) using a spline 'snake' segmentation method. RESULTS: A bilateral ventricular volume increase was found in schizophrenia. Whereas enlargement of the lateral ventricle (mean: 54%) as a whole was related to age of onset and was greater in females than in males, enlargement of the temporal horn (mean: 54%) was not strongly related to age of onset or sex. Lateral ventricle volume was negatively correlated with STG, fusiform and parahippocampal volume in schizophrenia. Hemispheric volumes were unchanged. CONCLUSIONS: The differing correlates of the components of ventricular enlargement suggest a degree of selectivity of the disease process with a focus in the temporal lobe.
Authors: V M Verkhlyutov; G V Gapienko; V L Ushakov; G V Portnova; I A Verkhlyutova; N V Anisimov; Yu A Pirogov Journal: Neurosci Behav Physiol Date: 2010-02-13
Authors: Jun Konishi; Elisabetta C Del Re; Sylvain Bouix; Gabriëlla A M Blokland; Raquelle Mesholam-Gately; Kristen Woodberry; Margaret Niznikiewicz; Jill Goldstein; Yoshio Hirayasu; Tracey L Petryshen; Larry J Seidman; Martha E Shenton; Robert W McCarley Journal: Brain Imaging Behav Date: 2018-08 Impact factor: 3.978
Authors: Guillermo Horga; Javier Bernacer; Nicola Dusi; Jonathan Entis; Kingwai Chu; Erin A Hazlett; M Mehmet Haznedar; Eileen Kemether; William Byne; Monte S Buchsbaum Journal: Eur Arch Psychiatry Clin Neurosci Date: 2011-03-24 Impact factor: 5.270
Authors: Qi Li; Charlton Cheung; Ran Wei; Edward S Hui; Joram Feldon; Urs Meyer; Sookja Chung; Siew E Chua; Pak C Sham; Ed X Wu; Grainne M McAlonan Journal: PLoS One Date: 2009-07-24 Impact factor: 3.240