OBJECTIVE: To assess pregnancy outcome in women with anaemia during pregnancy. METHODS: The study design involved a retrospective chart review of all women registering for prenatal care in the area of Kuopio University Hospital between 1990 and 2000. A haemoglobin concentration below 100g/l was used as a cutoff for anaemia and affected women (N=597) were stratified by the trimester at which anaemia was diagnosed. Multiple regression analysis was used to compare obstetric outcomes in the study groups and in non-anaemic women (N=22,202). RESULTS: The frequency of anaemia was 2.6%, with 0.3% occurring in the first trimester. After controlling for confounding factors, anaemia detected in the first trimester was associated with low-birth-weight infants (OR=3.14, 95% CI: 1.35-7.28) whereas the mid- and third-trimester anaemia groups showed no significantly different outcomes when compared with the non-anaemic women. First trimester anaemia was not significantly associated with small birth weight for gestational age (OR=0.98, 95% CI: 0.41-2.17) or with premature delivery <37 weeks (OR=1.80, 95% CI: 0.72-4.49). CONCLUSIONS: Maternal anaemia detected in the first trimester is associated with low birth weight.
OBJECTIVE: To assess pregnancy outcome in women with anaemia during pregnancy. METHODS: The study design involved a retrospective chart review of all women registering for prenatal care in the area of Kuopio University Hospital between 1990 and 2000. A haemoglobin concentration below 100g/l was used as a cutoff for anaemia and affected women (N=597) were stratified by the trimester at which anaemia was diagnosed. Multiple regression analysis was used to compare obstetric outcomes in the study groups and in non-anaemic women (N=22,202). RESULTS: The frequency of anaemia was 2.6%, with 0.3% occurring in the first trimester. After controlling for confounding factors, anaemia detected in the first trimester was associated with low-birth-weight infants (OR=3.14, 95% CI: 1.35-7.28) whereas the mid- and third-trimester anaemia groups showed no significantly different outcomes when compared with the non-anaemic women. First trimester anaemia was not significantly associated with small birth weight for gestational age (OR=0.98, 95% CI: 0.41-2.17) or with premature delivery <37 weeks (OR=1.80, 95% CI: 0.72-4.49). CONCLUSIONS:Maternal anaemia detected in the first trimester is associated with low birth weight.
Authors: Caroline E W Herr; Miroslav Dostal; Rakesh Ghosh; Paul Ashwood; Michael Lipsett; Kent E Pinkerton; Radim Sram; Irva Hertz-Picciotto Journal: Environ Health Date: 2010-08-02 Impact factor: 5.984
Authors: Saurabh Mehta; Karim P Manji; Alicia M Young; Elizabeth R Brown; Charles Chasela; Taha E Taha; Jennifer S Read; Robert L Goldenberg; Wafaie W Fawzi Journal: Am J Clin Nutr Date: 2008-06 Impact factor: 7.045
Authors: S Jessani; S Saleem; M K Hoffman; S S Goudar; R J Derman; J L Moore; A Garces; L Figueroa; N F Krebs; J Okitawutshu; A Tshefu; C L Bose; M Mwenechanya; E Chomba; W A Carlo; P K Das; A Patel; P L Hibberd; F Esamai; E A Liechty; S Bucher; T L Nolen; M Koso-Thomas; M Miodovnik; E M McClure; R L Goldenberg Journal: BJOG Date: 2021-04-12 Impact factor: 7.331