Literature DB >> 1276534

The effect of aspirin on 5-hydroxytryptamine uptake and release by human platelets.

F Rendu.   

Abstract

The influence of aspirin on 5-hydroxytryptamine (5-HT) uptake and storage by human blood platelets has been investigated. Uptake of 5-HT was strongly inhibited. In 30 min aspirin released 50% of the 5-HT that had been incorporated into the platelets prior to the addition of the aspirin. These results are discussed in terms of possible interference with a 5-HT membrane receptor and the impairment of 5-HT storage in the dense granules.

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Year:  1976        PMID： 1276534      PMCID： PMC1667011          DOI： 10.1111/j.1476-5381.1976.tb07665.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  11 in total

1.  Flashing phenomenon in blood platelets stained with fluorescent basic drugs.

Authors:  H P Lorez; M Da Prada; A Pletscher
Journal:  Experientia       Date:  1975-05-15

2.  Interactions between 5-hydroxytryptamine and platelet lipid fractions.

Authors:  A J Marcus; L B Safier; H L Ullman
Journal:  Ciba Found Symp       Date:  1975

3.  Cell membrane damage, platelet stickiness and some effects of aspirin.

Authors:  J R O'Brien
Journal:  Br J Haematol       Date:  1969-12       Impact factor: 6.998

4.  Inhibition of adenosine diphosphate-induced secondary aggregation and other platelet functions by acetylsalicylic acid ingestion.

Authors:  M B Zucker; J Peterson
Journal:  Proc Soc Exp Biol Med       Date:  1968-02

5.  On the mechanism of platelet function inhibition by acetylsalicylic acid.

Authors:  H al-Mondhiry; A J Marcus; T H Spaet
Journal:  Proc Soc Exp Biol Med       Date:  1970-02

6.  Aspirin selectively inhibits prostaglandin production in human platelets.

Authors:  J B Smith; A L Willis
Journal:  Nat New Biol       Date:  1971-06-23

7.  Mechanism of prostaglandin biosynthesis. 3. Catecholamines and serotonin as coenzymes.

Authors:  C J Sih; C Takeguchi; P Foss
Journal:  J Am Chem Soc       Date:  1970-11-04       Impact factor: 15.419

8.  Uptake, metabolism, storage, and release of 5-hydroxytryptamine in blood platelets.

Authors:  M Da Prada; A Pletscher
Journal:  Res Clin Stud Headache       Date:  1970

9.  Serotonin receptors, VII. Activities of various pure gangliosides as the receptors.

Authors:  D W Woolley; B W Gommi
Journal:  Proc Natl Acad Sci U S A       Date:  1965-05       Impact factor: 11.205

10.  Relative activities on and uptake by human blood platelets of 5-hydroxytryptamine and several analogues.

Authors:  G V Born; K Juengjaroen; F Michal
Journal:  Br J Pharmacol       Date:  1972-01       Impact factor: 8.739
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  1 in total

1.  Aspirin at therapeutic concentrations does not affect 5-hydroxytryptamine uptake by platelets.

Authors:  A H Drummond; D E MacIntyre; H J Olverman
Journal:  Br J Pharmacol       Date:  1977-04       Impact factor: 8.739
  1 in total

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