Literature DB >> 12761150

Helicobacter pylori supernatants cause epithelial cytoskeletal disruption that is bacterial strain and epithelial cell line dependent but not toxin VacA dependent.

James R Bebb1, Darren P Letley, Joanne L Rhead, John C Atherton.   

Abstract

We show here that Helicobacter pylori broth culture supernatants disrupt the actin cytoskeleton of epithelial cell lines, leading to cell rounding and apoptosis through anoikis. We demonstrate that there are marked quantitative differences between strains and that there are different cell line sensitivities. By constructing VacA null isogenic mutants, we show that the effect is not due to the vacuolating cytotoxin.

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Year:  2003        PMID： 12761150      PMCID： PMC155751          DOI： 10.1128/IAI.71.6.3623-3627.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  30 in total

1.  Cytoskeletal effects induced by pet, the serine protease enterotoxin of enteroaggregative Escherichia coli.

Authors:  F Navarro-García; C Sears; C Eslava; A Cravioto; J P Nataro
Journal:  Infect Immun       Date:  1999-05       Impact factor: 3.441

2.  Epithelial intestinal cell apoptosis induced by Helicobacter pylori depends on expression of the cag pathogenicity island phenotype.

Authors:  G Le'Negrate; V Ricci; V Hofman; B Mograbi; P Hofman; B Rossi
Journal:  Infect Immun       Date:  2001-08       Impact factor: 3.441

3.  Apoptosis in gastric epithelial cells is induced by Helicobacter pylori and accompanied by increased expression of BAK.

Authors:  G Chen; E M Sordillo; W G Ramey; J Reidy; P R Holt; S Krajewski; J C Reed; M J Blaser; S F Moss
Journal:  Biochem Biophys Res Commun       Date:  1997-10-20       Impact factor: 3.575

Review 4.  H. pylori virulence factors.

Authors:  J C Atherton
Journal:  Br Med Bull       Date:  1998       Impact factor: 4.291

5.  Helicobacter pylori vacuolating cytotoxin (VacA) disorganizes the cytoskeletal architecture of gastric epithelial cells.

Authors:  R Pai; T L Cover; A S Tarnawski
Journal:  Biochem Biophys Res Commun       Date:  1999-08-19       Impact factor: 3.575

6.  Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis.

Authors:  J Rudi; D Kuck; S Strand; A von Herbay; S M Mariani; P H Krammer; P R Galle; W Stremmel
Journal:  J Clin Invest       Date:  1998-10-15       Impact factor: 14.808

Review 7.  Helicobacter pylori and gastric carcinogenesis.

Authors:  P Correa
Journal:  Am J Surg Pathol       Date:  1995       Impact factor: 6.394

8.  Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii.

Authors:  A Nomura; G N Stemmermann; P H Chyou; I Kato; G I Perez-Perez; M J Blaser
Journal:  N Engl J Med       Date:  1991-10-17       Impact factor: 91.245

9.  Bacteroides fragilis enterotoxin induces cytoskeletal changes and surface blebbing in HT-29 cells.

Authors:  G Donelli; A Fabbri; C Fiorentini
Journal:  Infect Immun       Date:  1996-01       Impact factor: 3.441

10.  Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.

Authors:  T L Cover; M K Tummuru; P Cao; S A Thompson; M J Blaser
Journal:  J Biol Chem       Date:  1994-04-08       Impact factor: 5.157
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  5 in total

1.  Serum-free culture of H pylori intensifies cytotoxicity.

Authors:  Hiroyuki Ohno; Akiyuki Murano
Journal:  World J Gastroenterol       Date:  2007-01-28       Impact factor: 5.742

2.  Effects of Helicobacter pylori on the cadherin-catenin complex.

Authors:  J R Bebb; L Leach; A Zaitoun; N Hand; D P Letley; R Thomas; J C Atherton
Journal:  J Clin Pathol       Date:  2006-05-05       Impact factor: 3.411

3.  Helicobacter pylori upregulates matrilysin (MMP-7) in epithelial cells in vivo and in vitro in a Cag dependent manner.

Authors:  J R Bebb; D P Letley; R J Thomas; F Aviles; H M Collins; S A Watson; N M Hand; A Zaitoun; J C Atherton
Journal:  Gut       Date:  2003-10       Impact factor: 23.059

4.  Helicobacter pylori damages human gallbladder epithelial cells in vitro.

Authors:  Dong-Feng Chen; Lu Hu; Ping Yi; Wei-Wen Liu; Dian-Chun Fang; Hong Cao
Journal:  World J Gastroenterol       Date:  2008-12-07       Impact factor: 5.742

5.  Helicobacter pylori stimulates dendritic cells to induce interleukin-17 expression from CD4+ T lymphocytes.

Authors:  Wafa Khamri; Marjorie M Walker; Peter Clark; John C Atherton; Mark R Thursz; Kathleen B Bamford; Robert I Lechler; Giovanna Lombardi
Journal:  Infect Immun       Date:  2009-11-16       Impact factor: 3.441
  5 in total

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