Literature DB >> 12760679

Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp. II. Isolation, characterization, and structure determination.

John E Leet1, Wenying Li, Helen A Ax, James A Matson, Stella Huang, Ron Huang, Joseph L Cantone, Dieter Drexler, Richard A Dalterio, Kin S Lam.   

Abstract

A new group of thiazolyl peptide antibiotics, the nocathiacins, was isolated from cultured broth of Nocardia sp. The major analogs nocathiacins I-III (1-3) were purified using silica gel and Sephadex LH-20 chromatography techniques. The structures of nocathiacins I-III were determined by spectroscopic (2D-NMR, MSn) methods, and share structural similarities to glycothiohexide-alpha (4).

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Year:  2003        PMID: 12760679     DOI: 10.7164/antibiotics.56.232

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  14 in total

Review 1.  Small-molecule inhibitors of human LDH5.

Authors:  Carlotta Granchi; Ilaria Paterni; Reshma Rani; Filippo Minutolo
Journal:  Future Med Chem       Date:  2013-10       Impact factor: 3.808

Review 2.  A comprehensive review of glycosylated bacterial natural products.

Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal:  Chem Soc Rev       Date:  2015-11-07       Impact factor: 54.564

Review 3.  Thiazolyl peptide antibiotic biosynthesis: a cascade of post-translational modifications on ribosomal nascent proteins.

Authors:  Christopher T Walsh; Michael G Acker; Albert A Bowers
Journal:  J Biol Chem       Date:  2010-06-03       Impact factor: 5.157

4.  The dehydroalanine effect in the fragmentation of ions derived from polypeptides.

Authors:  Alice L Pilo; Zhou Peng; Scott A McLuckey
Journal:  J Mass Spectrom       Date:  2016-10       Impact factor: 1.982

5.  Fixing the Unfixable: The Art of Optimizing Natural Products for Human Medicine.

Authors:  Audrey E Yñigez-Gutierrez; Brian O Bachmann
Journal:  J Med Chem       Date:  2019-04-26       Impact factor: 7.446

6.  Characterization of NocL involved in thiopeptide nocathiacin I biosynthesis: a [4Fe-4S] cluster and the catalysis of a radical S-adenosylmethionine enzyme.

Authors:  Qi Zhang; Dandan Chen; Jun Lin; Rijing Liao; Wei Tong; Zhinan Xu; Wen Liu
Journal:  J Biol Chem       Date:  2011-03-29       Impact factor: 5.157

7.  New synthetic technology for the construction of N-hydroxyindoles and synthesis of nocathiacin I model systems.

Authors:  K C Nicolaou; Anthony A Estrada; Graeme C Freestone; Sang Hyup Lee; Xavier Alvarez-Mico
Journal:  Tetrahedron       Date:  2007-07-02       Impact factor: 2.457

Review 8.  Bioactive heterocycles containing endocyclic N-hydroxy groups.

Authors:  Reshma Rani; Carlotta Granchi
Journal:  Eur J Med Chem       Date:  2014-11-18       Impact factor: 6.514

9.  Antimicrobial evaluation of nocathiacins, a thiazole peptide class of antibiotics.

Authors:  Michael J Pucci; Joanne J Bronson; John F Barrett; Kenneth L DenBleyker; Linda F Discotto; Joan C Fung-Tomc; Yasutsugu Ueda
Journal:  Antimicrob Agents Chemother       Date:  2004-10       Impact factor: 5.191

10.  Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework.

Authors:  Yi Yu; Lian Duan; Qi Zhang; Rijing Liao; Ying Ding; Haixue Pan; Evelyn Wendt-Pienkowski; Gongli Tang; Ben Shen; Wen Liu
Journal:  ACS Chem Biol       Date:  2009-10-16       Impact factor: 5.100

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