Literature DB >> 12753908

A molecular mechanism for the low-pH stability of sialidase activity of influenza A virus N2 neuraminidases.

Tadanobu Takahashi1, Takashi Suzuki, Kazuya I-P Jwa Hidari, Daisei Miyamoto, Yasuo Suzuki.   

Abstract

Four human pandemic influenza A virus strains isolated in 1957 and 1968, but not most of the epidemic strains isolated after 1968, possess sialidase activity under low-pH conditions. Here, we used cell-expressed neuraminidases (NAs) to determine the region of the N2 NA that is associated with low-pH stability of sialidase activity. We found that consensus amino acid regions responsible for low-pH stability did not exist in pandemic NAs but that two amino acid substitutions in the low-pH-stable A/Hong Kong/1/68 (H3N2) NA and a single substitution in the low-pH-unstable A/Texas/68 (H2N2) NA resulted in significant change in low-pH stability.

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Year:  2003        PMID： 12753908     DOI： 10.1016/s0014-5793(03)00403-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

1.  Sialidase activity of influenza A virus in an endocytic pathway enhances viral replication.

Authors:  Takashi Suzuki; Tadanobu Takahashi; Chao-Tan Guo; Kazuya I-P Jwa Hidari; Daisei Miyamoto; Hideo Goto; Yoshihiro Kawaoka; Yasuo Suzuki
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

2.  Live Imaging of Virus-Infected Cells by Using a Sialidase Fluorogenic Probe.

Authors:  Tadanobu Takahashi; Yuuki Kurebayashi; Tadamune Otsubo; Kiyoshi Ikeda; Akira Minami; Takashi Suzuki
Journal:  Methods Mol Biol       Date:  2021

3.  Replication and transmission of mammalian-adapted H9 subtype influenza virus in pigs and quail.

Authors:  Adebimpe O Obadan; Brian J Kimble; Daniela Rajao; Kelly Lager; Jefferson J S Santos; Amy Vincent; Daniel R Perez
Journal:  J Gen Virol       Date:  2015-05-18       Impact factor: 3.891

4.  Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture.

Authors:  Xiangwu Ju; Yiwu Yan; Qiang Liu; Ning Li; Miaomiao Sheng; Lifang Zhang; Xiao Li; Zhu Liang; Fengming Huang; Kangtai Liu; Yan Zhao; Yanxu Zhang; Zhen Zou; Jianchao Du; Ying Zhong; Huandi Zhou; Peng Yang; Huijun Lu; Mingyao Tian; Dangsheng Li; Jianming Zhang; Ningyi Jin; Chengyu Jiang
Journal:  J Virol       Date:  2015-08-05       Impact factor: 5.103

5.  Influenza virus neuraminidase: structure and function.

Authors:  Y A Shtyrya; L V Mochalova; N V Bovin
Journal:  Acta Naturae       Date:  2009-07       Impact factor: 1.845

6.  Amino acid determinants conferring stable sialidase activity at low pH for H5N1 influenza A virus neuraminidase.

Authors:  Tadanobu Takahashi; Chairul A Nidom; Mai Thi Quynh Le; Takashi Suzuki; Yoshihiro Kawaoka
Journal:  FEBS Open Bio       Date:  2012-09-05       Impact factor: 2.693

7.  The low-pH stability discovered in neuraminidase of 1918 pandemic influenza A virus enhances virus replication.

Authors:  Tadanobu Takahashi; Yuuki Kurebayashi; Kumiko Ikeya; Takashi Mizuno; Keijo Fukushima; Hiroko Kawamoto; Yoshihiro Kawaoka; Yasuo Suzuki; Takashi Suzuki
Journal:  PLoS One       Date:  2010-12-09       Impact factor: 3.240

8.  Genomic and protein structural maps of adaptive evolution of human influenza A virus to increased virulence in the mouse.

Authors:  Jihui Ping; Liya Keleta; Nicole E Forbes; Samar Dankar; William Stecho; Shaun Tyler; Yan Zhou; Lorne Babiuk; Hana Weingartl; Rebecca A Halpin; Alex Boyne; Jayati Bera; Jessicah Hostetler; Nadia B Fedorova; Katie Proudfoot; Dan A Katzel; Tim B Stockwell; Elodie Ghedin; David J Spiro; Earl G Brown
Journal:  PLoS One       Date:  2011-06-30       Impact factor: 3.240

9.  Imaging of influenza virus sialidase activity in living cells.

Authors:  Yuuki Kurebayashi; Tadanobu Takahashi; Tadamune Otsubo; Kiyoshi Ikeda; Shunsaku Takahashi; Maiko Takano; Takashi Agarikuchi; Tsubasa Sato; Yukino Matsuda; Akira Minami; Hiroaki Kanazawa; Yuko Uchida; Takehiko Saito; Yoshihiro Kawaoka; Toshihiro Yamada; Fumihiko Kawamori; Robin Thomson; Mark von Itzstein; Takashi Suzuki
Journal:  Sci Rep       Date:  2014-05-02       Impact factor: 4.379

10.  Mutations in NA that induced low pH-stability and enhanced the replication of pandemic (H1N1) 2009 influenza A virus at an early stage of the pandemic.

Authors:  Tadanobu Takahashi; Jiasheng Song; Takashi Suzuki; Yoshihiro Kawaoka
Journal:  PLoS One       Date:  2013-05-16       Impact factor: 3.240
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