Literature DB >> 12750962

Establishment of a method of anonymization of DNA samples in genetic research.

Kazuo Hara1,2, Kazuhiko Ohe3, Takashi Kadowaki2, Naoya Kato4, Yasushi Imai1, Katsushi Tokunaga5, Ryozo Nagai1, Masao Omata4.   

Abstract

As the number of the genetic studies has rapidly increased in recent years, there has been growing concern that the privacy of the participants in such studies can be invaded unless effective measures are adopted to protect confidentiality. It is crucial for the scientific community to establish a method to anonymize DNA samples so that the public will trust genetic researchers. Here, we present a reliable and practical method of making DNA samples used in the genetic research anonymous. It assures complete anonymity by coding samples and personal information twice. Since it does not require equipment, such as bar-code readers or a software package, its cost is nominal compared with the laboratory costs. All institutions engaged in genetic research may wish to take measures such as the one described here to ensure the privacy and confidentiality of the participants in their genetic studies.

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Year:  2003        PMID: 12750962     DOI: 10.1007/s10038-003-0022-6

Source DB:  PubMed          Journal:  J Hum Genet        ISSN: 1434-5161            Impact factor:   3.172


  9 in total

1.  Privacy in genetics research.

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Journal:  Science       Date:  1999-08-27       Impact factor: 47.728

2.  Association analysis of nine missense polymorphisms in the coagulation factor V gene with severe preeclampsia in pregnant Japanese women.

Authors:  Hideki Watanabe; Hiromi Hamada; Naoki Yamada; Satoshi Sohda; Kimiko Yamakawa-Kobayashi; Hiroyuki Yoshikawa; Tadao Arinami
Journal:  J Hum Genet       Date:  2002       Impact factor: 3.172

3.  Guidelines for genetic testing. The Japan Society of Human Genetics, Council Committee of Ethics.

Authors:  I Matsuda; N Niikawa; K Sato; K Suzumori; Y Fukushima; N Fujiki; I Kanazawa; Y Nakamura; S Yonemoto; Y Nakagome
Journal:  J Hum Genet       Date:  2001       Impact factor: 3.172

4.  Genetic discrimination--an overblown fear?

Authors:  Dorothy C Wertz
Journal:  Nat Rev Genet       Date:  2002-07       Impact factor: 53.242

5.  A test for the insurance industry.

Authors:  R J Pokorski
Journal:  Nature       Date:  1998-02-26       Impact factor: 49.962

6.  Association of a polymorphism of the transforming growth factor-beta1 gene with blood pressure in Japanese individuals.

Authors:  Yoshiji Yamada; Michiko Fujisawa; Fujiko Ando; Naoakira Niino; Masashi Tanaka; Hiroshi Shimokata
Journal:  J Hum Genet       Date:  2002       Impact factor: 3.172

7.  An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and common carotid atherosclerosis.

Authors:  R Kawamoto; K Kohara; Y Tabara; T Miki; T Doi; H Tokunaga; I Konishi
Journal:  J Hum Genet       Date:  2001       Impact factor: 3.172

8.  Mutation and association analysis of the interferon regulatory factor 2 gene (IRF2) with atopic dermatitis.

Authors:  Y Nishio; E Noguchi; S Ito; E Ichikawa; Y Umebayashi; F Otsuka; T Arinami
Journal:  J Hum Genet       Date:  2001       Impact factor: 3.172

9.  Protection of privacy by third-party encryption in genetic research in Iceland.

Authors:  J R Gulcher; K Kristjánsson; H Gudbjartsson; K Stefánsson
Journal:  Eur J Hum Genet       Date:  2000-10       Impact factor: 4.246

  9 in total
  3 in total

Review 1.  Strategies for de-identification and anonymization of electronic health record data for use in multicenter research studies.

Authors:  Clete A Kushida; Deborah A Nichols; Rik Jadrnicek; Ric Miller; James K Walsh; Kara Griffin
Journal:  Med Care       Date:  2012-07       Impact factor: 2.983

2.  Re-identification of familial database records.

Authors:  Bradley Malin
Journal:  AMIA Annu Symp Proc       Date:  2006

3.  Polymorphism of OAS-1 determines liver fibrosis progression in hepatitis C by reduced ability to inhibit viral replication.

Authors:  Chang-Zheng Li; Naoya Kato; Jin-Hai Chang; Ryosuke Muroyama; Run-Xuan Shao; Narayan Dharel; Radsamee Sermsathanasawadi; Takao Kawabe; Masao Omata
Journal:  Liver Int       Date:  2009-06-05       Impact factor: 5.828

  3 in total

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