| Literature DB >> 12749895 |
Owen B Wallace1, Kenneth S Lauwers, Scott A Jones, Jeffrey A Dodge.
Abstract
A new series of estrogen receptor ligands based on a 6-hydroxy-tetrahydroquinoline scaffold is described, in addition to their binding affinity and functional activity in MCF-7 cells. Several 1,2-disubstituted tetrahydroquinolines bearing a basic side chain were shown to be high affinity ligands and antagonists in the MCF-7 proliferation assay. Compounds lacking the basic side chain were agonists in the MCF-7 assay.Entities:
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Year: 2003 PMID： 12749895 DOI： 10.1016/s0960-894x(03)00306-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823