Michael Guschmann1, Wolfgang Henrich, Joachim W Dudenhausen. 1. Department of Pediatric Pathology and Placentologie, Charité, Campus-Virchow-Klinikum, Medical Faculty of Humboldt University Berlin, Germany. Michael.Guschmann@charite.de
Abstract
AIMS: Chorioangiomas are benign tumors of the hemochorial placenta. They are malformations or hamartomas, formed as a result of defective angiogenesis. They are of clinical importance due to their association with premature placental release and pre-eclampsia. METHODS: Since a link has been established in neoplasias between tumor growth and an increased expression of angiogenic growth factors, 136 samples of chorioangiomas and 136 samples of tumor-free placental tissue were examined in terms of proliferation rate and expression of the growth factors angiopoietin-1 and -2, the angiopoietin-receptor Tie-2, PDGF and the PDFG beta-receptor. RESULTS: The chorioangiomas exhibited differing proliferation rates, whereas tumor-free placental tissue barely proliferated at all. Angiopoietin expression was--morphologically--considerably higher within the chorioangiomas than in the comparison placentas; morphological amounts of the Tie-2 receptor were identical in all samples. Expression of PDGF and its receptor was the same for chorioangiomas and tumor-free placentas. CONCLUSIONS: According to this study and the current literature in the field of hamartomas and some neoplasia, we can assume that increased growth factor expression plays a role in the formation of chorioangiomas, since it stimulates proliferation in a wide variety of cell compartments.
AIMS: Chorioangiomas are benign tumors of the hemochorial placenta. They are malformations or hamartomas, formed as a result of defective angiogenesis. They are of clinical importance due to their association with premature placental release and pre-eclampsia. METHODS: Since a link has been established in neoplasias between tumor growth and an increased expression of angiogenic growth factors, 136 samples of chorioangiomas and 136 samples of tumor-free placental tissue were examined in terms of proliferation rate and expression of the growth factors angiopoietin-1 and -2, the angiopoietin-receptor Tie-2, PDGF and the PDFG beta-receptor. RESULTS: The chorioangiomas exhibited differing proliferation rates, whereas tumor-free placental tissue barely proliferated at all. Angiopoietin expression was--morphologically--considerably higher within the chorioangiomas than in the comparison placentas; morphological amounts of the Tie-2 receptor were identical in all samples. Expression of PDGF and its receptor was the same for chorioangiomas and tumor-free placentas. CONCLUSIONS: According to this study and the current literature in the field of hamartomas and some neoplasia, we can assume that increased growth factor expression plays a role in the formation of chorioangiomas, since it stimulates proliferation in a wide variety of cell compartments.
Authors: Pardis Hosseinzadeh; Alireza A Shamshirsaz; Pouya Javadian; Jimmy Espinoza; Manisha Gandhi; Rodrigo Ruano; Darrell L Cass; Oluyinka A Olutoye; Michael A Belfort Journal: AJP Rep Date: 2015-08-03