Literature DB >> 12745015

Aminocarboxylate complexes and octreotide complexes with no carrier added 177Lu, 166Ho and 149Pm.

Wen Ping Li1, C Jeff Smith, Cathy S Cutler, Timothy J Hoffman, Alan R Ketring, Silvia S Jurisson.   

Abstract

Several aminocarboxylate complexes of the "no carrier added" (NCA) radiolanthanides (149)Pm, (166)Ho and (177)Lu were evaluated using our in vitro hydroxyapatite and serum stability model and in vivo in normal CF-1 mice [10]. The aminocarboxylate chelates evaluated with the NCA radiolanthanides for in vitro stability were EDTA, CDTA, DTPA, MA-DTPA and DOTA. In addition, the NCA radiolanthanide complexes with DTPA-octreotide (DTPA-OCT) were synthesized and evaluated, as a model for a peptide conjugated aminocarboxylate complex. The biodistribution studies of the NCA complexes with DTPA, DOTA and DTPA-OCT showed that the in vitro model correctly predicted the in vivo stability of the radiolanthanide complexes, with Ln-DOTA > Ln-DTPA > Ln-DTPA-OCT.

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Year:  2003        PMID： 12745015     DOI： 10.1016/s0969-8051(02)00418-3

Source DB:  PubMed          Journal:  Nucl Med Biol        ISSN： 0969-8051            Impact factor:   2.408


  6 in total

1.  Inorganic chemistry in nuclear imaging and radiotherapy: current and future directions.

Authors:  Valerie Carroll; Dustin W Demoin; Timothy J Hoffman; Silvia S Jurisson
Journal:  Radiochim Acta       Date:  2012-08       Impact factor: 1.440

Review 2.  Cutting edge rare earth radiometals: prospects for cancer theranostics.

Authors:  Alexander W E Sadler; Leena Hogan; Benjamin Fraser; Louis M Rendina
Journal:  EJNMMI Radiopharm Chem       Date:  2022-08-26

3.  153Sm and 166Ho complexes with tetraaza macrocycles containing pyridine and methylcarboxylate or methylphosphonate pendant arms.

Authors:  Fernanda Marques; Krassimira P Guerra; Lurdes Gano; Judite Costa; M Paula Campello; Luís M P Lima; Rita Delgado; Isabel Santos
Journal:  J Biol Inorg Chem       Date:  2004-08-28       Impact factor: 3.358

4.  Synthesis and biological evaluation of a novel decadentate ligand DEPA.

Authors:  Hyun-Soon Chong; Sooyoun Lim; Kwamena E Baidoo; Diane E Milenic; Xiang Ma; Fang Jia; Hyun A Song; Martin W Brechbiel; Michael R Lewis
Journal:  Bioorg Med Chem Lett       Date:  2008-09-19       Impact factor: 2.823

5.  Evaluation of DOTA-chelated neurotensin analogs with spacer-enhanced biological performance for neurotensin-receptor-1-positive tumor targeting.

Authors:  Yinnong Jia; Wen Shi; Zhengyuan Zhou; Nilesh K Wagh; Wei Fan; Susan K Brusnahan; Jered C Garrison
Journal:  Nucl Med Biol       Date:  2015-07-29       Impact factor: 2.408

6.  Facile transmetallation of [SbIII(DOTA)]- renders it unsuitable for medical applications.

Authors:  Catherine Chen; Charlotte Sommer; Helge Thisgaard; Vickie McKee; Christine J McKenzie
Journal:  RSC Adv       Date:  2022-02-16       Impact factor: 3.361
  6 in total

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