Valerie Carroll1, Dustin W Demoin1, Timothy J Hoffman2, Silvia S Jurisson1. 1. Chemistry, University of Missouri, Columbia, MO 65211, USA. 2. Chemistry, University of Missouri, Columbia, MO 65211, USA ; Internal Medicine, University of Missouri, Columbia, MO 65211, USA ; Harry S Truman Memorial Veterans Hospital, Columbia, MO 65211, USA.
Abstract
Radiometals play an important role in diagnostic and therapeutic radiopharmaceuticals. This field of radiochemistry is multidisciplinary, involving radiometal production, separation of the radiometal from its target, chelate design for complexing the radiometal in a biologically stable environment, specific targeting of the radiometal to its in vivo site, and nuclear imaging and/or radiotherapy applications of the resultant radiopharmaceutical. The critical importance of inorganic chemistry in the design and application of radiometal-containing imaging and therapy agents is described from a historical perspective to future directions.
Radiometals play anpan> importanpan>t role inpan> diagnostic anpan>d therapeutic radiopharmaceuticals. This field of radiochemistry is multidisciplinpan>ary, inpan>volvinpan>g radiopan> class="Chemical">metal production, separation of the radiometal from its target, chelate design for complexing the radiometal in a biologically stable environment, specific targeting of the radiometal to its in vivo site, and nuclear imaging and/or radiotherapy applications of the resultant radiopharmaceutical. The critical importance of inorganic chemistry in the design and application of radiometal-containing imaging and therapy agents is described from a historical perspective to future directions.
Entities:
Keywords:
Bifunctional chelates; Nuclear imaging; Radiometals; Radiotherapy; Specific targeting
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