Literature DB >> 12743318

The G glycoprotein of respiratory syncytial virus depresses respiratory rates through the CX3C motif and substance P.

Ralph A Tripp1, Azzeddine Dakhama, Les P Jones, Albert Barskey, Erwin W Gelfand, Larry J Anderson.   

Abstract

Respiratory syncytial virus (RSV) infection in the neonate can alter respiratory rates, i.e., lead to episodes of apnea. We show that RSV G glycoprotein reduces respiratory rates associated with the induction of substance P (SP) and G glycoprotein-CX3CR1 interaction, an effect that is inhibited by treatment with anti-G glycoprotein, anti-SP, or anti-CX3CR1 monoclonal antibodies. These data suggest new approaches for treating some aspects of RSV disease.

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Year:  2003        PMID： 12743318      PMCID： PMC155004          DOI： 10.1128/jvi.77.11.6580-6584.2003

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  46 in total

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2.  Impact of respiratory virus infections on persons with chronic underlying conditions.

Authors:  W P Glezen; S B Greenberg; R L Atmar; P A Piedra; R B Couch
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3.  Respiratory syncytial virus infection and G and/or SH protein expression contribute to substance P, which mediates inflammation and enhanced pulmonary disease in BALB/c mice.

Authors:  R A Tripp; D Moore; J Winter; L J Anderson
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

4.  Respiratory syncytial virus G and/or SH protein alters Th1 cytokines, natural killer cells, and neutrophils responding to pulmonary infection in BALB/c mice.

Authors:  R A Tripp; D Moore; L Jones; W Sullender; J Winter; L J Anderson
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

5.  Transfer of the enhancing effect of respiratory syncytial virus infection on subsequent allergic airway sensitization by T lymphocytes.

Authors:  J Schwarze; M Mäkelä; G Cieslewicz; A Dakhama; M Lahn; T Ikemura; A Joetham; E W Gelfand
Journal:  J Immunol       Date:  1999-11-15       Impact factor: 5.422

6.  Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBötzinger complex.

Authors:  P A Gray; J C Rekling; C M Bocchiaro; J L Feldman
Journal:  Science       Date:  1999-11-19       Impact factor: 47.728

7.  Respiratory syncytial virus G and/or SH glycoproteins modify CC and CXC chemokine mRNA expression in the BALB/c mouse.

Authors:  R A Tripp; L Jones; L J Anderson
Journal:  J Virol       Date:  2000-07       Impact factor: 5.103

8.  Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microglia.

Authors:  D Maciejewski-Lenoir; S Chen; L Feng; R Maki; K B Bacon
Journal:  J Immunol       Date:  1999-08-01       Impact factor: 5.422

9.  Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia.

Authors:  J K Harrison; Y Jiang; S Chen; Y Xia; D Maciejewski; R K McNamara; W J Streit; M N Salafranca; S Adhikari; D A Thompson; P Botti; K B Bacon; L Feng
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

10.  Atypical pulmonary eosinophilia is mediated by a specific amino acid sequence of the attachment (G) protein of respiratory syncytial virus.

Authors:  P W Tebbey; M Hagen; G E Hancock
Journal:  J Exp Med       Date:  1998-11-16       Impact factor: 14.307
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  41 in total

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Authors:  Gertrud U Radu; Hayat Caidi; Congrong Miao; Ralph A Tripp; Larry J Anderson; Lia M Haynes
Journal:  J Virol       Date:  2010-06-30       Impact factor: 5.103

2.  Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins.

Authors:  Monali M Bera; Bao Lu; Thomas R Martin; Shun Cui; Lawrence M Rhein; Craig Gerard; Norma P Gerard
Journal:  J Immunol       Date:  2011-09-14       Impact factor: 5.422

3.  CX3CR1 is an important surface molecule for respiratory syncytial virus infection in human airway epithelial cells.

Authors:  Tatiana Chirkova; Songbai Lin; Antonius G P Oomens; Kelsey A Gaston; Seyhan Boyoglu-Barnum; Jia Meng; Christopher C Stobart; Calvin U Cotton; Tina V Hartert; Martin L Moore; Assem G Ziady; Larry J Anderson
Journal:  J Gen Virol       Date:  2015-06-25       Impact factor: 3.891

4.  Mutating the CX3C Motif in the G Protein Should Make a Live Respiratory Syncytial Virus Vaccine Safer and More Effective.

Authors:  S Boyoglu-Barnum; S O Todd; J Meng; T R Barnum; T Chirkova; L M Haynes; S J Jadhao; R A Tripp; A G Oomens; M L Moore; L J Anderson
Journal:  J Virol       Date:  2017-04-28       Impact factor: 5.103

5.  Effects of anti-g and anti-f antibodies on airway function after respiratory syncytial virus infection.

Authors:  Junyan Han; Katsuyuki Takeda; Meiqin Wang; Wanjiang Zeng; Yi Jia; Yoshiki Shiraishi; Masakazu Okamoto; Azzeddine Dakhama; Erwin W Gelfand
Journal:  Am J Respir Cell Mol Biol       Date:  2014-07       Impact factor: 6.914

6.  RNA interference inhibits respiratory syncytial virus replication and disease pathogenesis without inhibiting priming of the memory immune response.

Authors:  Wenliang Zhang; Ralph A Tripp
Journal:  J Virol       Date:  2008-09-25       Impact factor: 5.103

Review 7.  Human genetic factors and respiratory syncytial virus disease severity.

Authors:  Isao Miyairi; John P DeVincenzo
Journal:  Clin Microbiol Rev       Date:  2008-10       Impact factor: 26.132

8.  Serum mannose-binding lectin levels are linked with respiratory syncytial virus (RSV) disease.

Authors:  Lucas Zimon Giacomini Ribeiro; Ralph A Tripp; Lívia Maria Gonçalves Rossi; Patrícia Vianna Bonini Palma; Jonny Yokosawa; Orlando Cesar Mantese; Thelma Fátima Mattos Oliveira; Lysa Luiz Nepomuceno; Divina Aparecida Oliveira Queiróz
Journal:  J Clin Immunol       Date:  2007-10-20       Impact factor: 8.317

9.  Prophylaxis with a respiratory syncytial virus (RSV) anti-G protein monoclonal antibody shifts the adaptive immune response to RSV rA2-line19F infection from Th2 to Th1 in BALB/c mice.

Authors:  Seyhan Boyoglu-Barnum; Tatiana Chirkova; Sean O Todd; Thomas R Barnum; Kelsey A Gaston; Patricia Jorquera; Lia M Haynes; Ralph A Tripp; Martin L Moore; Larry J Anderson
Journal:  J Virol       Date:  2014-07-02       Impact factor: 5.103

10.  Vaccination to induce antibodies blocking the CX3C-CX3CR1 interaction of respiratory syncytial virus G protein reduces pulmonary inflammation and virus replication in mice.

Authors:  Wenliang Zhang; Youngjoo Choi; Lia M Haynes; Jennifer L Harcourt; Larry J Anderson; Les P Jones; Ralph A Tripp
Journal:  J Virol       Date:  2009-10-28       Impact factor: 5.103
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