Literature DB >> 10415068

Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microglia.

D Maciejewski-Lenoir1, S Chen, L Feng, R Maki, K B Bacon.   

Abstract

Molecular analyses of the chemokine fractalkine and its receptor CX3C-R1 in the rat brain have revealed a striking polarization: fractalkine is expressed constitutively in neurons and is up-regulated by TNF-alpha and IL-1beta in astrocytes. Expression of its specific receptor, CX3C-R1, is restricted to astrocytes and microglia. We have analyzed the functional correlates of this expression and demonstrate that fractalkine induces microglial cell migration and activation. However, the activity of this chemokine on astrocytes may also be highly relevant in inducing astrocyte-microglia cell interactions through cytokine/mediator release leading to microglial activation.

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Year:  1999        PMID： 10415068

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  88 in total

Review 1.  Role of chemokines in inflammation and immunoregulation.

Authors:  L Feng
Journal:  Immunol Res       Date:  2000       Impact factor: 2.829

2.  Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses.

Authors:  P Fraticelli; M Sironi; G Bianchi; D D'Ambrosio; C Albanesi; A Stoppacciaro; M Chieppa; P Allavena; L Ruco; G Girolomoni; F Sinigaglia; A Vecchi; A Mantovani
Journal:  J Clin Invest       Date:  2001-05       Impact factor: 14.808

Review 3.  Regulation of microglial activation in stroke.

Authors:  Shou-Cai Zhao; Ling-Song Ma; Zhao-Hu Chu; Heng Xu; Wen-Qian Wu; Fudong Liu
Journal:  Acta Pharmacol Sin       Date:  2017-03-06       Impact factor: 6.150

Review 4.  Chemokines and glial cells: a complex network in the central nervous system.

Authors:  Elena Ambrosini; Francesca Aloisi
Journal:  Neurochem Res       Date:  2004-05       Impact factor: 3.996

5.  The impact of glial activation in the aging brain.

Authors:  Aileen M Lynch; Kevin J Murphy; Brian F Deighan; Julie-Ann O'Reilly; Yuri K Gun'ko; Thelma R Cowley; Rodrigo E Gonzalez-Reyes; Marina A Lynch
Journal:  Aging Dis       Date:  2010-09-04       Impact factor: 6.745

6.  Fractalkine attenuates excito-neurotoxicity via microglial clearance of damaged neurons and antioxidant enzyme heme oxygenase-1 expression.

Authors:  Mariko Noda; Yukiko Doi; Jianfeng Liang; Jun Kawanokuchi; Yoshifumi Sonobe; Hideyuki Takeuchi; Tetsuya Mizuno; Akio Suzumura
Journal:  J Biol Chem       Date:  2010-11-11       Impact factor: 5.157

7.  Pancreatic stellate cells and CX3CR1: occurrence in normal pancreas and acute and chronic pancreatitis and effect of their activation by a CX3CR1 agonist.

Authors:  Masahiko Uchida; Tetsuhide Ito; Taichi Nakamura; Masayuki Hijioka; Hisato Igarashi; Takamasa Oono; Masaki Kato; Kazuhiko Nakamura; Koichi Suzuki; Ryoichi Takayanagi; Robert T Jensen
Journal:  Pancreas       Date:  2014-07       Impact factor: 3.327

Review 8.  Toll-like receptors in chronic pain.

Authors:  Lauren Nicotra; Lisa C Loram; Linda R Watkins; Mark R Hutchinson
Journal:  Exp Neurol       Date:  2011-10-06       Impact factor: 5.330

Review 9.  Role of microglia in central nervous system infections.

Authors:  R Bryan Rock; Genya Gekker; Shuxian Hu; Wen S Sheng; Maxim Cheeran; James R Lokensgard; Phillip K Peterson
Journal:  Clin Microbiol Rev       Date:  2004-10       Impact factor: 26.132

10.  Regulation of dynamic behavior of retinal microglia by CX3CR1 signaling.

Authors:  Katharine J Liang; Jung Eun Lee; Yunqing D Wang; Wenxin Ma; Aurora M Fontainhas; Robert N Fariss; Wai T Wong
Journal:  Invest Ophthalmol Vis Sci       Date:  2009-05-14       Impact factor: 4.799
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