Literature DB >> 12739864

Hepatic EROD activity is not a useful biomarker of polychlorinated biphenyl exposure in the adult herring gull (Larus argentatus).

Sean W Kennedy1, Glen A Fox, Stephanie P Jones, Suzanne F Trudeau.   

Abstract

Liver concentrations of polychlorinated biphenyls (PCBs) and chicken embryo hepatocyte (CEH) bioassay-derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TCDD-EQs) were measured in livers of adult herring gulls (Larus argentatus) collected from several locations on the Great Lakes and two reference sites. Total PCB concentrations (sum of 42 congeners) and TCDD-EQ concentrations were compared with hepatic ethoxyresorufin-O-deethylase (EROD) activity, methoxyresorufin-O-deethylase (MROD) activity and immunodetectable cytochrome P4501A (CYP1A) protein concentration. EROD and MROD activity were not significantly correlated with total PCB concentration or TCDD-EQ concentration in liver tissue. CYP1A protein concentration was significantly correlated with total PCB concentration, but the linear relationship had little predictive power. We conclude that EROD is not a useful biomarker of PCB exposure in the adult herring gull.

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Year:  2003        PMID： 12739864     DOI： 10.1023/a:1022594424983

Source DB:  PubMed          Journal:  Ecotoxicology        ISSN： 0963-9292            Impact factor:   2.823


  25 in total

1.  Efficient analysis of cytochrome P4501A catalytic activity, porphyrins, and total proteins in chicken embryo hepatocyte cultures with a fluorescence plate reader.

Authors:  S W Kennedy; S P Jones; L J Bastien
Journal:  Anal Biochem       Date:  1995-04-10       Impact factor: 3.365

2.  Characterization and stability of rat liver microsomes isolated by a rapid gel filtration method.

Authors:  K Pyykkö
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1983-01

3.  Halogenated aromatic hydrocarbon-mediated porphyrin accumulation and induction of cytochrome P4501A in chicken embryo hepatocytes.

Authors:  A Lorenzen; S W Kennedy; L J Bastien; M E Hahn
Journal:  Biochem Pharmacol       Date:  1997-02-07       Impact factor: 5.858

Review 4.  Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs).

Authors:  S Safe
Journal:  Crit Rev Toxicol       Date:  1990       Impact factor: 5.635

5.  Microcontaminants and reproductive impairment of the Forster's tern on Green Bay, Lake Michigan--1983.

Authors:  T J Kubiak; H J Harris; L M Smith; T R Schwartz; D L Stalling; J A Trick; L Sileo; D E Docherty; T C Erdman
Journal:  Arch Environ Contam Toxicol       Date:  1989-09       Impact factor: 2.804

6.  An evaluation of the etiology of reduced CYP1A1 messenger RNA expression in the Atlantic tomcod from the Hudson River, New York, USA, using reverse transcriptase polymerase chain reaction analysis.

Authors:  N K Roy; S Courtenay; Z Yuan; M Ikonomou; I Wirgin
Journal:  Environ Toxicol Chem       Date:  2001-05       Impact factor: 3.742

7.  Cytochrome P4501A induction in avian hepatocyte cultures: a promising approach for predicting the sensitivity of avian species to toxic effects of halogenated aromatic hydrocarbons.

Authors:  S W Kennedy; A Lorenzen; S P Jones; M E Hahn; J J Stegeman
Journal:  Toxicol Appl Pharmacol       Date:  1996-11       Impact factor: 4.219

8.  Catalytic and immunochemical characterization of hepatic microsomal cytochromes P450 in beluga whale (Delphinapterus leucas).

Authors:  R D White; M E Hahn; W L Lockhart; J J Stegeman
Journal:  Toxicol Appl Pharmacol       Date:  1994-05       Impact factor: 4.219

9.  Sensitivity of embryos from duck, goose, herring gull, and various chicken breeds to 3,3',4,4'-tetrachlorobiphenyl.

Authors:  B Brunström
Journal:  Poult Sci       Date:  1988-01       Impact factor: 3.352

10.  Hepatic microsomal ethoxyresorufin O-deethylase-inducing potency in ovo and cytosolic Ah receptor binding affinity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: comparison of four avian species.

Authors:  J T Sanderson; G D Bellward
Journal:  Toxicol Appl Pharmacol       Date:  1995-05       Impact factor: 4.219
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  2 in total

1.  DNA strand length and EROD activity in relation to two screening measures of genotoxic exposure in Great Lakes herring gulls.

Authors:  Glen A Fox; Paul A White; Suzanne Trudeau; Chris Theodorakis; Laird J Shutt; Sean W Kennedy; Kim J Fernie
Journal:  Ecotoxicology       Date:  2005-10-12       Impact factor: 2.823

2.  Biological effects of marine PCB contamination on black guillemot nestlings at Saglek, Labrador: liver biomarkers.

Authors:  Zou Zou A Kuzyk; Neil M Burgess; Jason P Stow; Glen A Fox
Journal:  Ecotoxicology       Date:  2003 Feb-Aug       Impact factor: 2.823
  2 in total

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