Literature DB >> 12738653

Lymphocyte transformation test for medicinal herbs yields false-positive results for first-visit patients.

Naoki Mantani1, Toshiaki Kogure, Jun'ichi Tamura, Yutaka Shimada, Katsutoshi Terasawa.   

Abstract

We performed lymphocyte transformation tests (LTTs) for toki (angelicae radix) and ogon (scutellariae radix) on first-visit patients who had never taken Kampo medicines. LTTs for both herbs were positive in 12 of 14 patients, suggesting that LTTs for these herbs are unreliable for the diagnosis of Kampo medicine-induced liver injury.

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Year:  2003        PMID： 12738653      PMCID： PMC154964          DOI： 10.1128/cdli.10.3.479-480.2003

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  9 in total

1.  Fractionation and characterization of mitogenic and anti-complementary active fractions from kampo (Japanese Herbal) medicine "juzen-taiho-to".

Authors:  H Yamada; H Kiyohara; J C Cyong; N Takemoto; Y Komatsu; H Kawamura; M Aburada; E Hosoya
Journal:  Planta Med       Date:  1990-08       Impact factor: 3.352

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Authors:  P HOLLAND; A M MAUER
Journal:  Lancet       Date:  1964-06-20       Impact factor: 79.321

3.  Mitogenic and complement activating activities of the herbal components of juzen-taiho-to.

Authors:  H Yamada; H Kiyohara; N Takemoto; J F Zhao; H Kawamura; Y Komatsu; J C Cyong; M Aburada; E Hosoya
Journal:  Planta Med       Date:  1992-04       Impact factor: 3.352

4.  [Acute hepatic disorders induced by drugs. Clinical and laboratory observations of 30 cases (author's transl)].

Authors:  T Namihisa; K Yamaguchi; N Kitami
Journal:  Nihon Shokakibyo Gakkai Zasshi       Date:  1974-03

5.  Lymphocyte transformation test in the diagnosis of immediate type hypersensitivity reactions to penicillins.

Authors:  A J Bircher
Journal:  Curr Probl Dermatol       Date:  1995

6.  A useful diagnostic method for drug-induced pneumonitis: a case report.

Authors:  A Kawasaki; Y Mizushima; H Kunitani; M Kitagawa; M Kobayashi
Journal:  Am J Chin Med       Date:  1994       Impact factor: 4.667

7.  Incidence and clinical features of liver injury related to Kampo (Japanese herbal) medicine in 2,496 cases between 1979 and 1999: problems of the lymphocyte transformation test as a diagnostic method.

Authors:  N Mantani; T Kogure; S Sakai; H Goto; N Shibahara; T Kita; Y Shimada; K Terasawa
Journal:  Phytomedicine       Date:  2002-05       Impact factor: 5.340

8.  Mitogenic activities in the protein fractions of crude drugs.

Authors:  Y Tachibana; K Kawanishi
Journal:  Planta Med       Date:  1992-06       Impact factor: 3.352

9.  Herbal medicine and false-positive results on lymphocyte transformation test.

Authors:  Naoki Mantani; Shinya Sakai; Toshiaki Kogure; Hirozo Goto; Naotoshi Shibahara; Toshiaki Kita; Yutaka Shimada; Katsutoshi Terasawa
Journal:  Yakugaku Zasshi       Date:  2002-06       Impact factor: 0.302
  9 in total
  10 in total

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Review 2.  Drug-Induced Liver Injury: Why is the Roussel Uclaf Causality Assessment Method (RUCAM) Still Used 25 Years After Its Launch?

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Journal:  Drug Saf       Date:  2018-08       Impact factor: 5.606

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Journal:  Allergy Asthma Clin Immunol       Date:  2007-06-15       Impact factor: 3.406

Review 4.  In vitro testing for the diagnosis of anticonvulsant hypersensitivity syndrome: a systematic review.

Authors:  Abdelbaset A Elzagallaai; Sandra R Knowles; Michael J Rieder; John R Bend; Neil H Shear; Gideon Koren
Journal:  Mol Diagn Ther       Date:  2009       Impact factor: 4.074

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6.  Edematous erythema at the hands and feet probably caused by the traditional herb "radix astragali".

Authors:  Toshiaki Kogure; Takeshi Tatsumi; Yuko Oku
Journal:  Integr Med Insights       Date:  2011-03-16

Review 7.  A report of an adult case of tubulointerstitial nephritis and uveitis (TINU) syndrome, with a review of 102 Japanese cases.

Authors:  Keiichiro Matsumoto; Kenichi Fukunari; Yuji Ikeda; Motoaki Miyazono; Tomoya Kishi; Ryoko Matsumoto; Makoto Fukuda; Saori Uchiumi; Mai Yoshizaki; Yasunori Nonaka; Akiko Kanaya
Journal:  Am J Case Rep       Date:  2015-02-28

8.  Recurrent Drug-induced Liver Injury Caused by the Incidental Readministration of a Kampo Formula Containing Scutellariae Radix.

Authors:  Yutaka Shimada; Makoto Fujimoto; Tatsuya Nogami; Hidetoshi Watari; Hideyuki Kitahara; Hiroki Misawa; Yoshiyuki Kimbara; Kei-Ichiro Kita
Journal:  Intern Med       Date:  2018-02-09       Impact factor: 1.271

9.  Utility of Basophil Activation Test in a Case of Daisaikoto- and Yokukansan-induced Lung Injury.

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10.  A Rare Case of Drug-Induced Liver Injury Caused by Levetiracetam.

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  10 in total

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