Literature DB >> 12735990

Synthesis and antihyperglycemic activity of suitably functionalized 3H-quinazolin-4-ones.

Vishnu Ji Ram1, Brajendra K Tripathi, Arvind K Srivastava.   

Abstract

A series of 2-sec-amino-3H-quinazolin-4-ones (4a-p) and 4-sec-amino-2-chloroquinazolines (5a-b) have been synthesized by nucleophilic substitution reaction of 2-chloro-4(3H)-quinazolones (3) and 2,4-dichloroquinazolines (2) with amines, respectively. Most of the synthesized compounds were evaluated for antihyperglycemic activity but only 4a,b,d,j,o displayed significant reduction in blood glucose level in streptozotocin and sucrose loaded rat models.

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Year:  2003        PMID： 12735990     DOI： 10.1016/s0968-0896(03)00142-1

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  9 in total

1.  Synthesis and biological evaluation studies of novel quinazolinone derivatives as antibacterial and anti-inflammatory agents.

Authors:  Mohamed F Zayed; Memy H Hassan
Journal:  Saudi Pharm J       Date:  2013-04-06       Impact factor: 4.330

2.  Therapeutic reactivation of mutant p53 protein by quinazoline derivatives.

Authors:  Hamish S Sutherland; In Young Hwang; Elaine S Marshall; Brent S Lindsay; William A Denny; Catherine Gilchrist; Wayne R Joseph; Debra Greenhalgh; Emma Richardson; Philip Kestell; Angela Ding; Bruce C Baguley
Journal:  Invest New Drugs       Date:  2011-09-13       Impact factor: 3.850

Review 3.  2,3-Dihydroquinazolin-4(1H)-one as a privileged scaffold in drug design.

Authors:  Mariateresa Badolato; Francesca Aiello; Nouri Neamati
Journal:  RSC Adv       Date:  2018-06-07       Impact factor: 4.036

4.  Synthesis and biological activity of arylsulfonamide derivatives containing 2-arylamino-4(3H)-quinazolinone.

Authors:  Zhigang Zeng; Tao Gao; Yan Li; Xiang Wang; Xuhong Yang; Minghu Wu
Journal:  J Pestic Sci       Date:  2016-11-20       Impact factor: 1.519

5.  Crystal structure of 2-benzamido-N-(2,2-di-eth-oxy-eth-yl)benzamide.

Authors:  Abdelaaziz Ouahrouch; Moha Taourirte; Hassan B Lazrek; Joachim W Engels; Michael Bolte
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-02-28

6.  Search for Compounds with Hypoglycemic Activity in the Series of 1-[2-(1H-Tetrazol-5-yl)-R(1)-phenyl]-3-R(2)-phenyl(ethyl)ureas and R(1)-Tetrazolo[1,5-c]quinazolin-5(6H)-ones.

Authors:  Oleksii M Antypenko; Sergiy I Kovalenko; Galina O Zhernova
Journal:  Sci Pharm       Date:  2015-10-10

7.  Synthesis, Spectroscopic Characterization, and Time-Dependent DFT Calculations of 1-Methyl-5-phenyl-5H-pyrido[1,2-a]quinazoline-3,6-dione and Its Starting Precursor in Different Solvents.

Authors:  Nagwa M M Hamada
Journal:  ChemistryOpen       Date:  2018-10-12       Impact factor: 2.911

8.  Quinazolinone-Amino Acid Hybrids as Dual Inhibitors of EGFR Kinase and Tubulin Polymerization.

Authors:  Mohamed F Zayed; Heba S Rateb; Sahar Ahmed; Osama A Khaled; Sabrin R M Ibrahim
Journal:  Molecules       Date:  2018-07-12       Impact factor: 4.411

9.  Design, Synthesis, Cytotoxic Evaluation and Molecular Docking of New Fluoroquinazolinones as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects.

Authors:  Mohamed F Zayed; Sahar Ahmed; Saleh Ihmaid; Hany E A Ahmed; Heba S Rateb; Sabrin R M Ibrahim
Journal:  Int J Mol Sci       Date:  2018-06-11       Impact factor: 5.923
  9 in total

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