Literature DB >> 1273584

Monoamine oxidase activity decreased in cells lacking hypoxanthine phosphoribosyltransferase activity.

X O Breakefield, C M Castiglione, S B Edelstein.   

Abstract

The Lesch-Nyhan syndrome in humans is characterized by lack of hypoxanthine phosphoribosyltransferase activity and neurologic abnormalities that suggest changes in catecholamine metabolism. Monoamine oxidase, which degrades biogenic amines, has decreased activity in noradrenergic murine neuroblastoma cell lines lacking hypoxanthine phosphoribosyltransferase activity and in skin fibroblasts from patients with the Lesch-Nyhan syndrome.

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Year:  1976        PMID： 1273584     DOI： 10.1126/science.1273584

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

Review 1.  Heberden oration 1979: human aberrations of purine metabolism and their significance for rheumatology.

Authors:  J E Seegmiller
Journal:  Ann Rheum Dis       Date:  1980-04       Impact factor: 19.103

2.  Monoamino oxidase activity reduced in cultured human fetal cells deficient in hypoxanthine-guanine phosphoribosyltransferase activity.

Authors:  S D Skaper; I A Schafer
Journal:  Biochem Genet       Date:  1978-12       Impact factor: 1.890

3.  Effect of riboflavin on monoamine oxidase activity in cultured neuroblastoma cells.

Authors:  V Bonnefil; C M Castiglione; R M Cawthon; X O Breakefield
Journal:  Cell Mol Neurobiol       Date:  1981-12       Impact factor: 5.046

4.  Human monoamine oxidase A gene determines levels of enzyme activity.

Authors:  G S Hotamisligil; X O Breakefield
Journal:  Am J Hum Genet       Date:  1991-08       Impact factor: 11.025

5.  Self-injury in Lesch-Nyhan disease.

Authors:  L T Anderson; M Ernst
Journal:  J Autism Dev Disord       Date:  1994-02

6.  Properties of monoamine oxidase in control and Lesch-Nyhan fibroblasts.

Authors:  M R Castro Costa; S B Edelstein; C M Castiglione; H Chao; X O Breakefield
Journal:  Biochem Genet       Date:  1980-06       Impact factor: 1.890

7.  Consequences of impaired purine recycling in dopaminergic neurons.

Authors:  J C Lewers; I Ceballos-Picot; T L Shirley; L Mockel; K Egami; H A Jinnah
Journal:  Neuroscience       Date:  2008-01-17       Impact factor: 3.590

8.  Extensive conjugation of dopamine (3,4-dihydroxyphenethylamine) metabolites in cultured human skin fibroblasts and rat hepatoma cells.

Authors:  P A Crooks; X O Breakefield; C H Sulens; C M Castiglione; J K Coward
Journal:  Biochem J       Date:  1978-10-15       Impact factor: 3.857
  8 in total

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