OBJECTIVE: We performed a prospective, randomized clinical trial to compare the usefulness of the minute ventilation test (MVT) with clinical judgement in predicting readiness for extubation in preterm newborns with respiratory distress syndrome requiring surfactant therapy and mechanical ventilation. STUDY DESIGN: A total of 42 preterm infants with respiratory distress syndrome were randomized when they reached preselected ventilator settings. The primary outcome measure was the time from study entry to extubation, provided the infant remained extubated for at least 24 hours. RESULTS: Infants evaluated by the MVT were extubated in a significantly shorter period of time (mean of 8 hours) than those evaluated clinically (mean of 36 hours). The extubation failure rate was similar in the two groups. CONCLUSION: The MVT is an easily performed objective measure that can be used to predict readiness for extubation in preterm infants. In this study, it significantly shortened the time for extubation and was not associated with a higher rate of reintubation.
RCT Entities:
OBJECTIVE: We performed a prospective, randomized clinical trial to compare the usefulness of the minute ventilation test (MVT) with clinical judgement in predicting readiness for extubation in preterm newborns with respiratory distress syndrome requiring surfactant therapy and mechanical ventilation. STUDY DESIGN: A total of 42 preterm infants with respiratory distress syndrome were randomized when they reached preselected ventilator settings. The primary outcome measure was the time from study entry to extubation, provided the infant remained extubated for at least 24 hours. RESULTS:Infants evaluated by the MVT were extubated in a significantly shorter period of time (mean of 8 hours) than those evaluated clinically (mean of 36 hours). The extubation failure rate was similar in the two groups. CONCLUSION: The MVT is an easily performed objective measure that can be used to predict readiness for extubation in preterm infants. In this study, it significantly shortened the time for extubation and was not associated with a higher rate of reintubation.
Authors: L Dupree Hatch; Peter H Grubb; Melinda H Markham; Theresa A Scott; William F Walsh; James C Slaughter; Ann R Stark; E Wesley Ely Journal: Am J Perinatol Date: 2017-05-11 Impact factor: 1.862
Authors: Joke M Wielenga; Agnes van den Hoogen; Henriette A van Zanten; Onno Helder; Bas Bol; Bronagh Blackwood Journal: Cochrane Database Syst Rev Date: 2016-03-21
Authors: Wissam Shalish; Lara J Kanbar; Smita Rao; Carlos A Robles-Rubio; Lajos Kovacs; Sanjay Chawla; Martin Keszler; Doina Precup; Karen Brown; Robert E Kearney; Guilherme M Sant'Anna Journal: BMC Pediatr Date: 2017-07-17 Impact factor: 2.125
Authors: Elie G Abu Jawdeh; Amrita Pant; Aayush Gabrani; M Douglas Cunningham; Thomas M Raffay; Philip M Westgate Journal: Children (Basel) Date: 2021-03-18