BACKGROUND:Vitamin E has a strong antioxidant capacity, and has been used in several ischemia-reperfusion studies. The aim of this study was to investigate the effects of water-soluble vitamin E (alpha-tocopherol) on myocardial protection during coronary artery surgery. METHODS:Water soluble vitamin E (100 mg) in tepid saline (n = 14) or tepid saline alone (n = 16) was administered into the coronary arteries at the end of aortic cross-clamping. Cardiac troponin-I (cTn-I), MB-isoenzyme of creatine kinase (CK-MB), myoglobin, blood gas, and lactate levels in systemic and coronary sinus blood and hemodynamic variables were assessed during and after the operation. RESULTS: Eight hours after reperfusion, cTn-I levels increased to 3.06 +/- 1.8 ng/ml and 6.97 +/- 3.9 ng/ml in the vitamin E group and control group, respectively (p = 0.01). Coronary sinus lactate concentration was 2.68 +/- 0.5 mmol/l in the vitamin E group and 4.01 +/- 1.5 mmol/l in the control group 60 minutes after reperfusion (p = 0.027). CONCLUSIONS: Administration of vitamin E into the coronary arteries before removal of the aortic cross-clamp can reduce myocardial cell injury and protect the myocardium from ischemia-reperfusion injury.
RCT Entities:
BACKGROUND:Vitamin E has a strong antioxidant capacity, and has been used in several ischemia-reperfusion studies. The aim of this study was to investigate the effects of water-soluble vitamin E (alpha-tocopherol) on myocardial protection during coronary artery surgery. METHODS:Water soluble vitamin E (100 mg) in tepid saline (n = 14) or tepid saline alone (n = 16) was administered into the coronary arteries at the end of aortic cross-clamping. Cardiac troponin-I (cTn-I), MB-isoenzyme of creatine kinase (CK-MB), myoglobin, blood gas, and lactate levels in systemic and coronary sinus blood and hemodynamic variables were assessed during and after the operation. RESULTS: Eight hours after reperfusion, cTn-I levels increased to 3.06 +/- 1.8 ng/ml and 6.97 +/- 3.9 ng/ml in the vitamin E group and control group, respectively (p = 0.01). Coronary sinus lactate concentration was 2.68 +/- 0.5 mmol/l in the vitamin E group and 4.01 +/- 1.5 mmol/l in the control group 60 minutes after reperfusion (p = 0.027). CONCLUSIONS: Administration of vitamin E into the coronary arteries before removal of the aortic cross-clamp can reduce myocardial cell injury and protect the myocardium from ischemia-reperfusion injury.
Authors: Bilgehan Erkut; Ahmet Özyazıcıoğlu; Bekir Sami Karapolat; Cevdet Uğur Koçoğulları; Sait Keles; Azman Ateş; Cemal Gundogdu; Hikmet Kocak Journal: Drug Target Insights Date: 2007-11-21
Authors: Sérvio A Bucioli; Luiz Carlos de Abreu; Vitor E Valenti; Claudio Leone; Helio Vannucchi Journal: BMC Complement Altern Med Date: 2011-12-20 Impact factor: 3.659
Authors: Ahmet Hazini; Mustafa Cemek; İbrahim Işıldak; Saadet Alpdağtaş; Abdullah Önül; Ünal Şenel; Tuba Kocaman; Ali Dur; Mustafa Iraz; Hüseyin Uyarel Journal: Postepy Kardiol Interwencyjnej Date: 2015-01-12 Impact factor: 1.426