Literature DB >> 12729671

Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus Desmos.

Jiu-Hong Wu1, Xi-Hong Wang, Yang-Hua Yi, Kuo-Hsiung Lee.   

Abstract

Sixteen flavonoids and their derivatives isolated from Desmos spp. were evaluated for inhibition of HIV replication in H9 lymphocyte cells. 2-Methoxy-3-methyl-4,6-dihydroxy-5-(3'-hydroxy)cinnamoylbenzaldehyde (12) and lawinal (6) demonstrated potent anti-HIV activity with EC(50) values of 0.022 and 2.30 microg/mL and therapeutic indexes of 489 and 45.2, respectively. Compound 12 appears to be an excellent lead for further anti-HIV drug development.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12729671     DOI： 10.1016/s0960-894x(03)00197-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  23 in total

Review 1.  Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.

Authors:  Kuo-Hsiung Lee
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050

Review 2.  Chalcone: A Privileged Structure in Medicinal Chemistry.

Authors:  Chunlin Zhuang; Wen Zhang; Chunquan Sheng; Wannian Zhang; Chengguo Xing; Zhenyuan Miao
Journal:  Chem Rev       Date:  2017-05-10       Impact factor: 60.622

3.  Synthesis of chroman aldehydes that inhibit HIV.

Authors:  George A Kraus; John Mengwasser; Wendy Maury; ChoonSeok Oh
Journal:  Bioorg Med Chem Lett       Date:  2011-01-14       Impact factor: 2.823

4.  (E)-3-(2-Chloro-6-methyl-3-quinol-yl)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-en-1-one.

Authors:  Syed Umar Farooq Rizvi; Hamid Latif Siddiqui; Tanvir Hussain; Muhammad Azam; Masood Parvez
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-03-03

5.  Leishmania amazonensis growth inhibitors: biological and theoretical features of sulfonamide 4-methoxychalcone derivatives.

Authors:  Alessandra M T Souza; Helena C Castro; Monique A Brito; Carla R Andrighetti-Fröhner; Uiaran Magalhães; Kely N Oliveira; Daniela Gaspar-Silva; Letícia K Pacheco; Antônio C Joussef; Mário Steindel; Cláudia M O Simões; Dilvani O Santos; Magaly G Albuquerque; Carlos R Rodrigues; Ricardo J Nunes
Journal:  Curr Microbiol       Date:  2009-07-23       Impact factor: 2.188

6.  Straightforward synthesis of thiazoline-incorporated chalconoids from phenacyl halides.

Authors:  Adile Ayati; Saeed Emami
Journal:  Mol Divers       Date:  2013-01-12       Impact factor: 2.943

7.  An efficient and facile synthesis of 3-amino-5-chromenyl-butenolides from 3-formyl chromone, dialkyl acetylenedicarboxylate, and primary amines.

Authors:  Saeed Balalaie; Morteza Ashouriha; Frank Rominger; Hamid Reza Bijanzadeh
Journal:  Mol Divers       Date:  2013-01-23       Impact factor: 2.943

8.  Preclinical development of the green tea catechin, epigallocatechin gallate, as an HIV-1 therapy.

Authors:  Christina L Nance; Edward B Siwak; William T Shearer
Journal:  J Allergy Clin Immunol       Date:  2009-02       Impact factor: 10.793

9.  The blockade of formyl peptide-induced respiratory burst by 2',5'-dihydroxy-2-furfurylchalcone involves phospholipase D signaling in neutrophils.

Authors:  Jih-Pyang Wang; Ling-Chu Chang; Mei-Feng Hsu; Chun-Nan Lin
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-08-20       Impact factor: 3.000

10.  Synthesis and cytotoxicity of chalcones and 5-deoxyflavonoids.

Authors:  Jing Zhang; Xin-Ling Fu; Nan Yang; Qiu-An Wang
Journal:  ScientificWorldJournal       Date:  2013-06-06
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.