| Literature DB >> 12727618 |
Ilmi Okazaki1, Kiyotsugu Yoshikawa, Kazou Kinoshita, Masamichi Muramatsu, Hitoshi Nagaoka, Tasaku Honjo.
Abstract
Activation-induced cytidine deaminase (AID), a putative RNA-editing cytidine deaiminase that is expressed strictly in activated B cells, is indispensable in three apparently distinct genetic alterations of immunoglobulin genes-namely, class switch recombination, somatic hypermutation, and gene conversion. Recent findings led us to propose a common DNA cleaving mechanism, in which the transient secondary structure of the S and V region DNA is recognized by a nicking enzyme regulated by the putative RNA-editing activity of AID.Entities:
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Year: 2003 PMID： 12727618 DOI： 10.1111/j.1749-6632.2003.tb06027.x
Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691