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Literature DB >> 12727539

New substituted 2-(pyrazol-1-yl)-dialkylacetanilides with potential local anesthetic and antiarrhythmic action. Part II.

Mircea Iovu¹, Christina Zalaru, Florea Dumitrascu, Constantin Draghici, Mircea Moraru, Elena Cristea.

Abstract

Nine substituted 2-(pyrazol-1-yl)-dialkylacetanilides were synthesized by N-alkylation of pyrazole and its derivatives with several 2-iodoacetanilides. The new compounds exhibited local anesthetic and antiarrhythmic actions. They have been characterized by elemental chemical analysis, UV-Vis, IR, 1H NMR, 13C NMR, SM spectra and pharmacology research.

Entities: Chemical

Mesh：

Substances：

Year: 2003 PMID： 12727539 DOI： 10.1016/S0014-827X(02)00014-9

Source DB: PubMed Journal: Farmaco ISSN： 0014-827X

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Cited

4 in total

1. Synthesis and anti-HIV-1 screening of novel N'-(1-(aryl)ethylidene)-2-(5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-4(1H)-yl)acetohydrazides.

Authors: Sana Aslam; Matloob Ahmad; Muhammad Zia-Ur-Rehman; Catherine Montero; Mervi Detorio; Masood Parvez; Raymond F Schinazi
Journal: Arch Pharm Res Date: 2013-07-10 Impact factor: 4.946

New substituted 2-(pyrazol-1-yl)-dialkylacetanilides with potential local anesthetic and antiarrhythmic action. Part II.

1. Synthesis and anti-HIV-1 screening of novel N'-(1-(aryl)ethylidene)-2-(5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-4(1H)-yl)acetohydrazides.

2. Synthesis and antibacterial activity of novel curcumin derivatives containing heterocyclic moiety.

3. Ethyl 5-amino-1-(4-chloro-2-nitro-phen-yl)-1H-pyrazole-4-carboxyl-ate.

4. Synthesis, characterization and antimicrobial activity of some novel benzimidazole derivatives.