Literature DB >> 12726854

p53 mutations and resistance to chemotherapy: A stab in the back for p73.

Thierry Soussi1.   

Abstract

p73 is essential for apoptosis induced by many cytotoxic agents, but this function can be blocked by a particular category of p53 mutations that have consequently acquired a gain of function.

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Year:  2003        PMID： 12726854     DOI： 10.1016/s1535-6108(03)00081-3

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  4 in total

1.  Nutlin-3, the small-molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53.

Authors:  A K Arya; A El-Fert; T Devling; R M Eccles; M A Aslam; C P Rubbi; N Vlatković; J Fenwick; B H Lloyd; D R Sibson; T M Jones; M T Boyd
Journal:  Br J Cancer       Date:  2010-06-29       Impact factor: 7.640

2.  Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells.

Authors:  Liwei Liu; Lars Herfindal; Jouni Jokela; Tania Keiko Shishido; Matti Wahlsten; Stein Ove Døskeland; Kaarina Sivonen
Journal:  Mar Drugs       Date:  2014-04-03       Impact factor: 5.118

3.  Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma.

Authors:  Tongsen Zheng; Dalong Yin; Zhaoyang Lu; Jiabei Wang; Yuejin Li; Xi Chen; Yingjian Liang; Xuan Song; Shuyi Qi; Boshi Sun; Changming Xie; Xianzhi Meng; Shangha Pan; Jiaren Liu; Hongchi Jiang; Lianxin Liu
Journal:  Mol Cancer       Date:  2014-05-31       Impact factor: 27.401

4.  Pramlintide, an antidiabetic, is antineoplastic in colorectal cancer and synergizes with conventional chemotherapy.

Authors:  Maha S Al-Keilani; Dua H Alsmadi; Ruba S Darweesh; Karem H Alzoubi
Journal:  Clin Pharmacol       Date:  2018-03-05
  4 in total

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