Literature DB >> 12725571

Hepatoprotective and free radical scavenging effects of Nelumbo nucifera.

D H Sohn1, Y C Kim, S H Oh, E J Park, X Li, B H Lee.   

Abstract

Ethanol extracts from Nelumbo nucifera (ENN) seeds were studied for possible antioxidative and hepatoprotective effects. Antioxidative effects were measured spectrophotometrically by reduction of 2,2'-Diphenyl-1-picrylhydrazyl (DPPH) radicals. Hepatoprotective effects were tested using carbon tetrachloride (CCl4) and aflatoxin B1 (AFB1)-induced hepatocyte toxicity models. ENN showed potent free radical scavenging effects with a median inhibition concentration of 6.49 microg/ml. Treatment of hepatocytes with ENN inhibited both the production of serum enzymes and cytotoxicity by CCl4. The genotoxic and cytotoxic effects of AFB1 were also inhibited by ENN in dose-dependent manners. These hepatoprotective effects of ENN against CCl4 and AFB1 might result from its potent antioxidative properties.

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Year:  2003        PMID： 12725571     DOI： 10.1078/094471103321659889

Source DB:  PubMed          Journal:  Phytomedicine        ISSN： 0944-7113            Impact factor:   5.340


  23 in total

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