| Literature DB >> 12724229 |
Susan H Wei1, Robert Brown, Tim H-M Huang.
Abstract
Epigenetic regulation of gene expression has been observed in a variety of tumor types. We have used microarray technology to evaluate the predisposition of drug response by aberrant methylation in ovarian cancer. Results indicate that loss of gene activity due to hypermethylation potentially confers a predisposition in certain cancer types and is an early event in disease progression. Methylation profiles of ovarian cancer might be useful for early cancer detection and prediction of chemotherapy outcome in a clinical context.Entities:
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Year: 2003 PMID： 12724229 DOI： 10.1111/j.1749-6632.2003.tb05979.x
Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691