Literature DB >> 12723623

Gnetol as a potent tyrosinase inhibitor from genus Gnetum.

Kenji Ohguchi1, Toshiyuki Tanaka, Ibrahim Iliya, Tetsuro Ito, Munekazu Iinuma, Kenji Matsumoto, Yukihiro Akao, Yoshinori Nozawa.   

Abstract

Gnetol (2,3',5',6-tetrahydroxy-trans-stilbene), a naturally occurring compound particularly found in the genus Gnetum, had a strong inhibitory effect on murine tyrosinase activity. Gnetol (IC50, 4.5 microM) was stronger than kojic acid (IC50, 139 microM) as a standard inhibitor for murine tyrosinase activity. Moreover, gnetol significantly suppressed, melanin biosynthesis in murine B16 melanoma cells.

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Year:  2003        PMID： 12723623     DOI： 10.1271/bbb.67.663

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  11 in total

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