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Literature DB >> 1272266

A model for the binding of lac repressor to the lac operator.

G V Gursky, V G Tumanyan, A S Zasedatelev, A L Zhuze, S L Grokhovsky, B P Gottikh.

Abstract

A model is suggested for the lac repressor binding to the lac operator in which the repressor polypeptide chain sequences from Gly 14 to Ala 32 and from Ala 53 to Leu 71 are involved in specific interaction with operator DNA. A correspondence between the protein and DNA sequences is found which explains specificity of the repressor binding to the lac operator. The model can be extended to describe specific binding of other regulatory proteins to DNA.

Entities: Mutation

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Year: 1976 PMID： 1272266 DOI： 10.1007/BF00366265

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

16 in total

1. The predicted secondary structure of the N-terminal sequence of the lac repressor and proposed models for its complexation to the lac operator.

Authors: D J Patel
Journal: Biochemistry Date: 1975-03-11 Impact factor: 3.162

2. Genetic regulation: the Lac control region.

Authors: R C Dickson; J Abelson; W M Barnes; W S Reznikoff
Journal: Science Date: 1975-01-10 Impact factor: 47.728

3. The lac repressor protein: molecular shape, subunit structure, and proposed model for operator interaction based on structural studies of microcrystals.

Authors: T A Steitz; T J Richmond; D Wise; D Engelman
Journal: Proc Natl Acad Sci U S A Date: 1974-03 Impact factor: 11.205

4. Sequences of controlling regions of the lactose operon.

Authors: W Gilbert; N Maizels; A Maxam
Journal: Cold Spring Harb Symp Quant Biol Date: 1974

5. Altered sequences changing the operator-binding properties of the Lac repressor: colinearity of the repressor protein with the i-gene map.

Authors: K Weber; T Platt; D Ganem; J H Miller
Journal: Proc Natl Acad Sci U S A Date: 1972-12 Impact factor: 11.205

6. Genetic map of the lactose repressor gene (i) of Escherichia coli.

Authors: M Pfahl
Journal: Genetics Date: 1972-11 Impact factor: 4.562

7. Lac repressor. Specific proteolytic destruction of the NH 2 -terminal region and loss of the deoxyribonucleic acid-binding activity.

Authors: T Platt; J G Files; K Weber
Journal: J Biol Chem Date: 1973-01-10 Impact factor: 5.157

3. Specificity of DNA basic polypeptide interactions. II+ Influence of aromatic amino acid residues investigated with agarose bound lysine copolypeptides.

Authors: K Wehling; H A Arfmann; G Seipke; K G Wagner
Journal: Nucleic Acids Res Date: 1977-03 Impact factor: 16.971

3 in total

A model for the binding of lac repressor to the lac operator.

1. The predicted secondary structure of the N-terminal sequence of the lac repressor and proposed models for its complexation to the lac operator.

2. Genetic regulation: the Lac control region.

3. The lac repressor protein: molecular shape, subunit structure, and proposed model for operator interaction based on structural studies of microcrystals.

4. Sequences of controlling regions of the lactose operon.

5. Altered sequences changing the operator-binding properties of the Lac repressor: colinearity of the repressor protein with the i-gene map.

6. Genetic map of the lactose repressor gene (i) of Escherichia coli.

7. Lac repressor. Specific proteolytic destruction of the NH 2 -terminal region and loss of the deoxyribonucleic acid-binding activity.

8. The amino-acid sequence of lac repressor.

9. How lac repressor binds to DNA.

10. Translational restarts: AUG reinitiation of a lac repressor fragment.

1. lac repressor-lac operator interaction: NMR observations.

2. Form of DNA and the nature of interactions with proteins in chromatin.

3. Specificity of DNA basic polypeptide interactions. II+ Influence of aromatic amino acid residues investigated with agarose bound lysine copolypeptides.