Literature DB >> 12717527

Comparison of cytotoxicity of aminoglycoside antibiotics using a panel cellular biotest system.

V G Chernikov1, S M Terekhov, T B Krokhina, S S Shishkin, T D Smirnova, E A Kalashnikova, N V Adnoral, L B Rebrov, Yu I Denisov-Nikol'skii, V A Bykov.   

Abstract

The cytotoxicity of four aminoglycoside antibiotics was studied by estimation of the dose-effect relationship using a panel cellular biotest system including cell cultures for test objects. The cultures represented 4 differentiation types: normal human fibroblasts and myoblasts, human or Syrian hamster hepatoma cells, and mouse/mouse hybridoma cells. It was found that three widely used antibiotics gentamicin, kanamycin, and neomycin exhibit similar, but not identical cytotoxicity parameters and differ distinctly from geneticin. Hence, the proposed panel biotest system helps to quantitatively evaluate and differentiate the effects of bioactive substances with similar chemical structure.

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Year:  2003        PMID： 12717527     DOI： 10.1023/a:1023474719042

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  9 in total

1.  A mouse model for nonsense mutation bypass therapy shows a dramatic multiday response to geneticin.

Authors:  Chunmei Yang; Jinong Feng; Wenjia Song; Jicheng Wang; Becky Tsai; Yunwu Zhang; William A Scaringe; Kathleen A Hill; Paris Margaritis; Katherine A High; Steve S Sommer
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-19       Impact factor: 11.205

2.  Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations.

Authors:  Jeyakumar Kandasamy; Dana Atia-Glikin; Eli Shulman; Katya Shapira; Michal Shavit; Valery Belakhov; Timor Baasov
Journal:  J Med Chem       Date:  2012-11-29       Impact factor: 7.446

3.  The antibacterial activity of Ga3+ is influenced by ligand complexation as well as the bacterial carbon source.

Authors:  Olena Rzhepishevska; Barbro Ekstrand-Hammarström; Maximilian Popp; Erik Björn; Anders Bucht; Anders Sjöstedt; Henrik Antti; Madeleine Ramstedt
Journal:  Antimicrob Agents Chemother       Date:  2011-09-26       Impact factor: 5.191

Review 4.  Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases.

Authors:  Kim M Keeling; David M Bedwell
Journal:  Wiley Interdiscip Rev RNA       Date:  2011-07-06       Impact factor: 9.957

5.  G418-mediated ribosomal read-through of a nonsense mutation causing autosomal recessive proximal renal tubular acidosis.

Authors:  Rustam Azimov; Natalia Abuladze; Pakan Sassani; Debra Newman; Liyo Kao; Weixin Liu; Nicholas Orozco; Piotr Ruchala; Alexander Pushkin; Ira Kurtz
Journal:  Am J Physiol Renal Physiol       Date:  2008-07-09

6.  In vitro and ex vivo suppression by aminoglycosides of PCDH15 nonsense mutations underlying type 1 Usher syndrome.

Authors:  Annie Rebibo-Sabbah; Igor Nudelman; Zubair M Ahmed; Timor Baasov; Tamar Ben-Yosef
Journal:  Hum Genet       Date:  2007-07-25       Impact factor: 4.132

7.  Designer aminoglycosides that selectively inhibit cytoplasmic rather than mitochondrial ribosomes show decreased ototoxicity: a strategy for the treatment of genetic diseases.

Authors:  Eli Shulman; Valery Belakhov; Gao Wei; Ann Kendall; Esther G Meyron-Holtz; Dorit Ben-Shachar; Jochen Schacht; Timor Baasov
Journal:  J Biol Chem       Date:  2013-12-03       Impact factor: 5.157

8.  Translational read-through of a nonsense mutation causing Bartter syndrome.

Authors:  Hee Yeon Cho; Beom Hee Lee; Hae Il Cheong
Journal:  J Korean Med Sci       Date:  2013-06-03       Impact factor: 2.153

Review 9.  Dbp5/DDX19 between Translational Readthrough and Nonsense Mediated Decay.

Authors:  Christian Beißel; Sebastian Grosse; Heike Krebber
Journal:  Int J Mol Sci       Date:  2020-02-06       Impact factor: 5.923
  9 in total

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