Literature DB >> 12717039

An orphan gyrB in the Mycobacterium smegmatis genome uncovered by comparative genomics.

P Jain1, V Nagaraja.   

Abstract

DNA gyrase is an essential topoisomerase found in all bacteria. It is encoded by gyrB and gyrA genes. These genes are organized differently in different bacteria. Direct comparison of Mycobacterium tuberculosis and Mycobacterium smegmatis genomes reveals presence of an additional gyrB in M. smegmatis flanked by novel genes. Analysis of the amino acid sequence of GyrB from different organisms suggests that the orphan GyrB in M. smegmatis may have an important cellular role.

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Year:  2002        PMID: 12717039     DOI: 10.1007/BF02715907

Source DB:  PubMed          Journal:  J Genet        ISSN: 0022-1333            Impact factor:   1.166


  36 in total

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Journal:  Annu Rev Biochem       Date:  2001       Impact factor: 23.643

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Journal:  Genes Cells       Date:  1999-12       Impact factor: 1.891

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Journal:  J Mol Biol       Date:  1997-11-07       Impact factor: 5.469

7.  Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity.

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Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

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Journal:  Nature       Date:  1998-06-11       Impact factor: 49.962

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Journal:  Mol Microbiol       Date:  1996-04       Impact factor: 3.501

10.  Comparative genomics uncovers large tandem chromosomal duplications in Mycobacterium bovis BCG Pasteur.

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Journal:  Yeast       Date:  2000-06-30       Impact factor: 3.239

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  1 in total

1.  Delineating bacteriostatic and bactericidal targets in mycobacteria using IPTG inducible antisense expression.

Authors:  Parvinder Kaur; Saurabh Agarwal; Santanu Datta
Journal:  PLoS One       Date:  2009-06-15       Impact factor: 3.240

  1 in total

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