| Literature DB >> 1271403 |
M S Mirrlees, S J Moulton, C T Murphy, P J Taylor.
Abstract
A technique is presented for the direct measurement of octanol-water partition coefficients by HPLC. The method involves running solutes in octanol-saturated water as the mobile phase against water-saturated octanol entrained on an inert support. Log P correlates linearly with log tc for a number of standards. The measurable range in log P (so far) is -0.3 to +3.7. A critical review of chromatographic methods in Hansch analysis is given.Entities:
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Year: 1976 PMID： 1271403 DOI： 10.1021/jm00227a008
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446