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Literature DB >> 12704174

Humoral immunity reflects altered T helper cell bias in Borrelia burgdorferi-infected gamma delta T-cell-deficient mice.

Linda K Bockenstedt¹, Marie-Claude Shanafelt, Alexia Belperron, Jialing Mao, Stephen W Barthold.

Abstract

In murine Lyme borreliosis, the absence of gamma delta T lymphocytes augments the T helper cell 2 type humoral response but does not alter disease susceptibility. Arthropod transmission of Borrelia burgdorferi spirochetes results in similar antibody isotypes when gamma delta T cells are present, suggesting that vector effects can negate gamma delta T-cell functions in vivo.

Entities: Disease Species

Mesh：

Substances：

Year: 2003 PMID： 12704174 PMCID： PMC153287 DOI： 10.1128/IAI.71.5.2938-2940.2003

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

28 in total

Review 1. Gammadelta T cells: functional plasticity and heterogeneity.

Authors: Simon R Carding; Paul J Egan
Journal: Nat Rev Immunol Date: 2002-05 Impact factor: 53.106

2. Kinetics of Borrelia burgdorferi dissemination and evolution of disease after intradermal inoculation of mice.

Authors: S W Barthold; D H Persing; A L Armstrong; R A Peeples
Journal: Am J Pathol Date: 1991-08 Impact factor: 4.307

3. Ixodes scapularis: effects of repeated infestations with pathogen-free nymphs on macrophage and T lymphocyte cytokine responses of BALB/c and C3H/HeN mice.

Authors: G B Schoeler; S A Manweiler; S K Wikel
Journal: Exp Parasitol Date: 1999-08 Impact factor: 2.011

4. Delayed dissemination of Lyme disease spirochetes from the site of deposition in the skin of mice.

Authors: C M Shih; R J Pollack; S R Telford; A Spielman
Journal: J Infect Dis Date: 1992-10 Impact factor: 5.226

5. Chronic Lyme borreliosis in the laboratory mouse.

Authors: S W Barthold; M S de Souza; J L Janotka; A L Smith; D H Persing
Journal: Am J Pathol Date: 1993-09 Impact factor: 4.307

6. Immune protection and control of inflammatory tissue necrosis by gamma delta T cells.

Authors: Y X Fu; C E Roark; K Kelly; D Drevets; P Campbell; R O'Brien; W Born
Journal: J Immunol Date: 1994-10-01 Impact factor: 5.422

7. Gamma/delta T cell-deficient mice exhibit reduced disease severity and decreased inflammatory response in the brain in murine neurocysticercosis.

Authors: Astrid E Cardona; Judy M Teale
Journal: J Immunol Date: 2002-09-15 Impact factor: 5.422

Humoral immunity reflects altered T helper cell bias in Borrelia burgdorferi-infected gamma delta T-cell-deficient mice.

Review 1. Gammadelta T cells: functional plasticity and heterogeneity.

2. Kinetics of Borrelia burgdorferi dissemination and evolution of disease after intradermal inoculation of mice.

3. Ixodes scapularis: effects of repeated infestations with pathogen-free nymphs on macrophage and T lymphocyte cytokine responses of BALB/c and C3H/HeN mice.

4. Delayed dissemination of Lyme disease spirochetes from the site of deposition in the skin of mice.

5. Chronic Lyme borreliosis in the laboratory mouse.

6. Immune protection and control of inflammatory tissue necrosis by gamma delta T cells.

7. Gamma/delta T cell-deficient mice exhibit reduced disease severity and decreased inflammatory response in the brain in murine neurocysticercosis.

8. Lyme borreliosis in genetically resistant and susceptible mice with severe combined immunodeficiency.

9. Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini.

10. A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice.

1. Reduced immune response to Borrelia burgdorferi in the absence of γδ T cells.

2. The Classical Complement Pathway Is Required to Control Borrelia burgdorferi Levels During Experimental Infection.