Literature DB >> 2982989

Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini.

J M Ribeiro, G T Makoul, J Levine, D R Robinson, A Spielman.   

Abstract

Pilocarpine-induced saliva of the tick, Ixodes dammini, inhibited platelet aggregation triggered by ADP and collagen, as well as platelet-aggregation factor. In addition, we found apyrase activity (which degrades ATP and ADP to AMP and orthophosphate) and an anticoagulant. We showed the presence of prostaglandin E2 (PGE2) by bioassay and radioimmunoassay. This saliva inhibited interleukin 2 production by T cell hybridomas, an activity consistent with that of PGE2. A kininase was demonstrated, and this may counteract the algesia- and edema-promoting properties of PGE2. Together, these salivary components produce antihemostatic, antiinflammatory, and immunosuppressive effects that may facilitate feeding, as well as transmission of tick-borne pathogens.

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Year:  1985        PMID： 2982989      PMCID： PMC2187567          DOI： 10.1084/jem.161.2.332

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  29 in total

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  101 in total

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Authors:  Ruth R Montgomery; Denise Lusitani; Anne De Boisfleury Chevance; Stephen E Malawista
Journal:  Infect Immun       Date:  2004-05       Impact factor: 3.441

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Journal:  Ticks Tick Borne Dis       Date:  2012-01-02       Impact factor: 3.744

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Authors:  Ivo M B Francischetti; Thomas N Mather; José M C Ribeiro
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10.  The transcriptome of the salivary glands of the female western black-legged tick Ixodes pacificus (Acari: Ixodidae).

Authors:  Ivo M B Francischetti; Van My Pham; Ben J Mans; John F Andersen; Thomas N Mather; Robert S Lane; José M C Ribeiro
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