| Literature DB >> 12699764 |
David A Colby1, Wen Liu, James E Sheppeck, Hsien Bin Huang, Angus C Nairn, A Richard Chamberlin.
Abstract
A revised model of PP1-tautomycin (TM) complex suggests that this toxin does not bind in a conformation analogous to its structural cousin okadaic acid (OA), as has been assumed, but instead more resembles the mode of binding adopted by calyculin. This model rationalizes the unexpected potency of a truncated TM analogue lacking the bicyclic ketal common to TM and OA.Entities:
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Year: 2003 PMID： 12699764 DOI： 10.1016/s0960-894x(03)00106-9
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823