Literature DB >> 12699763

The selective inhibition of phosphatases by natural toxins: the anhydride domain of tautomycin is not a primary factor in controlling PP1/PP2A selectivity.

Wen Liu1, James E Sheppeck, David A Colby, Hsien-Bin Huang, Angus C Nairn, A Richard Chamberlin.   

Abstract

Analogues of the potent and moderately selective PP1/PP2A inhibitor tautomycin (TM) were prepared with modifications in the C1'-C7' anhydride moiety. While all retain varying degrees of activity within a 3000-fold range of potencies, they also show remarkable constancy in their IC(50) ratios, suggesting that the anhydride moiety is not critical in controlling the selectivity of inhibition.

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Year:  2003        PMID： 12699763     DOI： 10.1016/s0960-894x(03)00105-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis.

Authors:  Yinggang Luo; Wenli Li; Jianhua Ju; Qiuping Yuan; Noel R Peters; F Michael Hoffmann; Sheng-Xiong Huang; Tim S Bugni; Scott Rajski; Hiroyuki Osada; Ben Shen
Journal:  J Am Chem Soc       Date:  2010-05-19       Impact factor: 15.419

2.  Evans Enolates: Solution Structures of Lithiated Oxazolidinone-Derived Enolates.

Authors:  Evan H Tallmadge; David B Collum
Journal:  J Am Chem Soc       Date:  2015-10-05       Impact factor: 15.419

3.  Protein phosphatase 2A and neutral sphingomyelinase 2 regulate IRAK-1 protein ubiquitination and degradation in response to interleukin-1beta.

Authors:  Aneta Dobierzewska; Natalia V Giltiay; Sathish Sabapathi; Alexander A Karakashian; Mariana N Nikolova-Karakashian
Journal:  J Biol Chem       Date:  2011-06-27       Impact factor: 5.157

4.  Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors.

Authors:  Matthew S Kelker; Rebecca Page; Wolfgang Peti
Journal:  J Mol Biol       Date:  2008-11-01       Impact factor: 5.469

5.  All-codon scanning identifies p53 cancer rescue mutations.

Authors:  Roberta Baronio; Samuel A Danziger; Linda V Hall; Kirsty Salmon; G Wesley Hatfield; Richard H Lathrop; Peter Kaiser
Journal:  Nucleic Acids Res       Date:  2010-06-25       Impact factor: 16.971

6.  Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity.

Authors:  Jianhua Ju; Wenli Li; Qiuping Yuan; Noel R Peters; F Michael Hoffmann; Scott R Rajski; Hiroyuki Osada; Ben Shen
Journal:  Org Lett       Date:  2009-04-02       Impact factor: 6.005

7.  Lithium Amino Alkoxide-Evans Enolate Mixed Aggregates: Aldol Addition with Matched and Mismatched Stereocontrol.

Authors:  Janis Jermaks; Evan H Tallmadge; Ivan Keresztes; David B Collum
Journal:  J Am Chem Soc       Date:  2018-02-19       Impact factor: 15.419

8.  Asymmetric Synthesis of Homocitric Acid Lactone.

Authors:  Leslie A Nickerson; Valerie Huynh; Edward I Balmond; Stephen P Cramer; Jared T Shaw
Journal:  J Org Chem       Date:  2016-10-21       Impact factor: 4.354

9.  Structure-Reactivity Relationships in Lithiated Evans Enolates: Influence of Aggregation and Solvation on the Stereochemistry and Mechanism of Aldol Additions.

Authors:  Evan H Tallmadge; Janis Jermaks; David B Collum
Journal:  J Am Chem Soc       Date:  2015-12-24       Impact factor: 15.419

10.  Regulation of gap junction conductance by calcineurin through Cx43 phosphorylation: implications for action potential conduction.

Authors:  Rita I Jabr; Fiona S Hatch; Samantha C Salvage; Alejandro Orlowski; Paul D Lampe; Christopher H Fry
Journal:  Pflugers Arch       Date:  2016-10-19       Impact factor: 3.657
  10 in total

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