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Literature DB >> 1269611

Potentiation of ethanol narcosis by dopamine- and l-DOPA-based isoquinolines.

Abstract

The isoquinolines, salsolinol and 3-carboxysalsolinol, prolong ethanol-induced narcosis in mice. Pretreatment with carbidopa increases the effect of 3-carboxysalsolinol but not of salsolinol. These results suggest that ethanol sleeping-time potentiation by l-LOPA may involve a partial conversion to the isoquinoline in vivo. A central depressant action of salsolinol or the 3-carboxy analogue is suggested.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1976 PMID： 1269611 DOI： 10.1007/BF01937765

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

13 in total

1. Tetrahydroisoquinolines in vivo. I. Rat brain formation of salsolinol, a condensation product of dopamine and acetaldehyde, under certain conditions during ethanol intoxication.

Authors: M A Collins; M G Bigdeli
Journal: Life Sci Date: 1975-02-15 Impact factor: 5.037

2. Topographical differences in the cerebral metabolism of DL-2-14C-3,4-dihydroxphenylalanine.

Authors: A PLETSCHER; K F GEY
Journal: Experientia Date: 1962-11-15

3. Potentiation of the narcotic action and acute toxicity of alcohol by primary aromatic monoamines.

Authors: G ROSENFELD
Journal: Q J Stud Alcohol Date: 1960-12

4. Modification of Parkinsonism--chronic treatment with L-dopa.

Authors: G C Cotzias; P S Papavasiliou; R Gellene
Journal: N Engl J Med Date: 1969-02-13 Impact factor: 91.245

5. Synergy of ethanol and alcohol-like metabolites: tryptophol and 3,4-dihydroxyphenylethanol.

Authors: K Blum; W Calhoun; J H Merritt; J E Wallace
Journal: Pharmacology Date: 1973 Impact factor: 2.547

6. Tetrahydroisoquinoline alkaloids: in vivo metabolites of L-dopa in man.

Authors: M Sandler; S B Carter; K R Hunter; G M Stern
Journal: Nature Date: 1973-02-16 Impact factor: 49.962

7. Tetrahydroisoquinoline alkaloids: stimulated secretion from the adrenal medulla.

Authors: R S Greenberg; G Cohen
Journal: J Pharmacol Exp Ther Date: 1973-01 Impact factor: 4.030

8. Alkaloids' in mammalian tissues. I. Condensation of L-dopa and its two mono-O-methyl ethers with formaldehyde and acetaldehyde.

Authors: A Brossi; A Focella; S Teitel
Journal: Helv Chim Acta Date: 1972-01-31 Impact factor: 2.164

Potentiation of ethanol narcosis by dopamine- and l-DOPA-based isoquinolines.

1. Tetrahydroisoquinolines in vivo. I. Rat brain formation of salsolinol, a condensation product of dopamine and acetaldehyde, under certain conditions during ethanol intoxication.

2. Topographical differences in the cerebral metabolism of DL-2-14C-3,4-dihydroxphenylalanine.

3. Potentiation of the narcotic action and acute toxicity of alcohol by primary aromatic monoamines.

4. Modification of Parkinsonism--chronic treatment with L-dopa.

5. Synergy of ethanol and alcohol-like metabolites: tryptophol and 3,4-dihydroxyphenylethanol.

6. Tetrahydroisoquinoline alkaloids: in vivo metabolites of L-dopa in man.

7. Tetrahydroisoquinoline alkaloids: stimulated secretion from the adrenal medulla.

8. Alkaloids' in mammalian tissues. I. Condensation of L-dopa and its two mono-O-methyl ethers with formaldehyde and acetaldehyde.

9. Tryptophol, 5-hydroxytryptophol and 5-methoxytryptophol induced sleep in mice.

10. Brain sensitivity to alcohol in inbred mouse strains.

1. Analgesic effects of 3-carboxysalsolinol alone and in combination with morphine.

2. Ability of 3-carboxysalsolinol to produce ethanol-like discrimination in rats.